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J-104871
Catalog No. T24188Cas No. 191088-19-4
Alias UNII-6137X5QNJF, J104871, J 104871
J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
J-104871
Catalog No. T24188Alias UNII-6137X5QNJF, J104871, J 104871Cas No. 191088-19-4
J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | 10-14 weeks | |
| 5 mg | $483 | 10-14 weeks | |
| 10 mg | $692 | 10-14 weeks | |
| 25 mg | $1,080 | 10-14 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells. |
| In vitro | J 104871 inhibits Ras processing in H-ras-transformed NIH3T3 cells with an IC50 value of 3.1 μM and shows minimal inhibition of rat brain protein geranylgeranyltransferase-I or squalene synthase (SS)[1]. |
| In vivo | n female nude mice (8 weeks old) injected with activated H-ras-transformed NIH3T3 cells, J 104871 (40 mg/kg, 80 mg/kg; intraperitoneal injection; once daily; 6 days) suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells[1]. |
| Alias | UNII-6137X5QNJF, J104871, J 104871 |
| Molecular Weight | 708.67 |
| Formula | C38H32N2O12 |
| Cas No. | 191088-19-4 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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