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J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | 10-14 weeks | |
5 mg | $483 | 10-14 weeks | |
10 mg | $692 | 10-14 weeks | |
25 mg | $1,080 | 10-14 weeks |
Description | J-104871 (UNII-6137X5QNJF) is a novel farnesyltransferase (FTase) inhibitor that competitively blocks Ras farnesylation in vivo, inhibits Ras processing in activated H-ras-transformed NIH3T3 cells, and suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells. |
In vitro | J 104871 inhibits Ras processing in H-ras-transformed NIH3T3 cells with an IC50 value of 3.1 μM and shows minimal inhibition of rat brain protein geranylgeranyltransferase-I or squalene synthase (SS)[1]. |
In vivo | n female nude mice (8 weeks old) injected with activated H-ras-transformed NIH3T3 cells, J 104871 (40 mg/kg, 80 mg/kg; intraperitoneal injection; once daily; 6 days) suppresses tumor growth in nude mice transplanted with activated H-ras-transformed NIH3T3 cells[1]. |
Alias | UNII-6137X5QNJF, J104871, J 104871 |
Molecular Weight | 708.67 |
Formula | C38H32N2O12 |
Cas No. | 191088-19-4 |
Relative Density. | 1.495 g/cm3 (Predicted) |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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