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JC124

Catalog No. T25548Cas No. 1638611-48-9
Alias JC-124, JC 124

JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.

JC124

JC124

Purity: 98.54%
Catalog No. T25548Alias JC-124, JC 124Cas No. 1638611-48-9
JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
Pack SizePriceAvailabilityQuantity
1 mg$58In Stock
5 mg$148In Stock
10 mg$238In Stock
25 mg$398In Stock
50 mg$567In Stock
100 mg$768In Stock
200 mg$987In Stock
1 mL x 10 mM (in DMSO)$163In Stock
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Purity:98.54%
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Product Introduction

Bioactivity
Description
JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
In vitro
JC124 selectively inhibits NLRP3 inflammasome formation and activates caspase-1, and reduces IL-1β[1].
In vivo
In adult male Sprague-Dawley rats bearing traumatic brain injury, intraperitoneal administration of JC124 (100 mg/kg) reduces the number of injury-induced degenerating neurons, inflammatory cell response, and cortical lesion volume. JC124 decreases the expression of NLRP3, IL-1 beta, TNFα, ASC, iNOS, and caspase-1[1].
AliasJC-124, JC 124
Chemical Properties
Molecular Weight382.86
FormulaC17H19ClN2O4S
Cas No.1638611-48-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 225.0 mg/mL (587.7 mM), when pH is adjusted to 3 with HCl. Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6119 mL13.0596 mL26.1192 mL130.5960 mL
5 mM0.5224 mL2.6119 mL5.2238 mL26.1192 mL
10 mM0.2612 mL1.3060 mL2.6119 mL13.0596 mL
20 mM0.1306 mL0.6530 mL1.3060 mL6.5298 mL
50 mM0.0522 mL0.2612 mL0.5224 mL2.6119 mL
100 mM0.0261 mL0.1306 mL0.2612 mL1.3060 mL

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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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