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JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $58 | In Stock | |
5 mg | $148 | In Stock | |
10 mg | $238 | In Stock | |
25 mg | $398 | In Stock | |
50 mg | $567 | In Stock | |
100 mg | $768 | In Stock | |
200 mg | $987 | In Stock | |
1 mL x 10 mM (in DMSO) | $163 | In Stock |
Description | JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities. |
In vitro | JC124 selectively inhibits NLRP3 inflammasome formation and activates caspase-1, and reduces IL-1β[1]. |
In vivo | In adult male Sprague-Dawley rats bearing traumatic brain injury, intraperitoneal administration of JC124 (100 mg/kg) reduces the number of injury-induced degenerating neurons, inflammatory cell response, and cortical lesion volume. JC124 decreases the expression of NLRP3, IL-1 beta, TNFα, ASC, iNOS, and caspase-1[1]. |
Alias | JC-124, JC 124 |
Molecular Weight | 382.86 |
Formula | C17H19ClN2O4S |
Cas No. | 1638611-48-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225.0 mg/mL (587.7 mM), when pH is adjusted to 3 with HCl. Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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