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JC124

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Purity:98.54%

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COA HPLC HNMR

JC124

Catalog No. T25548Cas No. 1638611-48-9

JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.

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Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$247	In Stock
10 mg	$397	In Stock
25 mg	$663	In Stock
50 mg	$945	In Stock
100 mg	$1,280	In Stock
500 mg	$2,570	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Product Introduction

Bioactivity

Description	JC124 is an inhibitor of NLRP3 Inflammasome and exhibits neuroprotective and anti-inflammatory activities.
In vitro	JC124 selectively inhibits NLRP3 inflammasome formation and activates caspase-1, and reduces IL-1β[1].
In vivo	In adult male Sprague-Dawley rats bearing traumatic brain injury, intraperitoneal administration of JC124 (100 mg/kg) reduces the number of injury-induced degenerating neurons, inflammatory cell response, and cortical lesion volume. JC124 decreases the expression of NLRP3, IL-1 beta, TNFα, ASC, iNOS, and caspase-1[1].
Alias	JC 124, JC-124

Chemical Properties

Molecular Weight	382.86
Formula	C17H19ClN2O4S
Cas No.	1638611-48-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (587.7 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6119 mL	13.0596 mL	26.1192 mL	130.5960 mL
5 mM	0.5224 mL	2.6119 mL	5.2238 mL	26.1192 mL
10 mM	0.2612 mL	1.3060 mL	2.6119 mL	13.0596 mL
20 mM	0.1306 mL	0.6530 mL	1.3060 mL	6.5298 mL
50 mM	0.0522 mL	0.2612 mL	0.5224 mL	2.6119 mL
100 mM	0.0261 mL	0.1306 mL	0.2612 mL	1.3060 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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