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KG-548
🥰Excellent
Catalog No. T60539Cas No. 175205-09-1
Alias KG548
KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, binding to the β-fold surface involved in HIF-2 dimerization and coactivator recruitment, inhibiting lactate production and useful in cancer research.
KG-548
🥰Excellent
Purity: 99.62%
Catalog No. T60539Alias KG548Cas No. 175205-09-1
KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, binding to the β-fold surface involved in HIF-2 dimerization and coactivator recruitment, inhibiting lactate production and useful in cancer research.
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Purity:99.62%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | KG-548 is a dual inhibitor of ARNT/TACC3 and HIF-1α, binding to the β-fold surface involved in HIF-2 dimerization and coactivator recruitment, inhibiting lactate production and useful in cancer research. |
| In vitro | KG-548 (50 μM) significantly inhibited lactic acid production. [1] KG-548 (1 mM) significantly interfered with the binding of ARNT to one or both co-activators. KG-548 (0-2 mM, 16 h) decomposed the (320 μM) ARNT PAS-B/TACC3 complex in a dose-dependent manner in vitro and in cell lysates with an IC50 of 25 μM. [2] |
| Alias | KG548 |
| Molecular Weight | 282.15 |
| Formula | C9H4F6N4 |
| Cas No. | 175205-09-1 |
| Smiles | FC(F)(F)C1=CC(=CC(=C1)C(F)(F)F)C2=NN=NN2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (283.54 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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