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L-371,257
Catalog No. T15682Cas No. 162042-44-6
L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a.
L-371,257
Catalog No. T15682Cas No. 162042-44-6
L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 5 mg | $83 | In Stock | |
| 10 mg | $133 | In Stock | |
| 25 mg | $268 | In Stock | |
| 50 mg | $395 | In Stock | |
| 100 mg | $563 | In Stock |
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Purity:100%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | L-371,257 is a competitive antagonist of oxytocin receptor with pA2 of 8.4 and Ki of 19 nM. L-371,257 shows a Ki of 3.7 nM for vasopressin receptor 1a. |
| Targets&IC50 | OTR:(ki)19 nM, V1a receptor:3.7 nM(ki) |
| In vivo | L-371,257 (0.5 and 1.0 mg/kg; i.p.) stimulates weight gain (10.5 g) relative to vehicle treatment (4.7 g) in rats[3]. |
| Molecular Weight | 507.58 |
| Formula | C28H33N3O6 |
| Cas No. | 162042-44-6 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 8.1 mg/mL (16 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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