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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $88 | In Stock |
Description | L748337 is a competitive and potent β3-adrenoceptor antagonist that inhibits the action of β3-, β2-, and β1-adrenoceptors, activates MAPK signaling, promotes phosphorylation of Erk1/2, and inhibits the protective effects of CL316243, and is used in the study of disorders caused by abnormalities of the β3-adrenoceptors. |
In vitro | The β3-adrenergic receptor selective antagonist L748337 (100nM) partially antagonized the relaxation induced by (-)-isoprenaline in cav-1KO arteries, but did not antagonize the relaxation in WT arteries[1]. |
In vivo | L748337 (5 mg/kg) exhibits anti-cancer effects in male C57BL/6 J mice (8 weeks of age) bearing syngeneic B16F10 cells[1]. |
Alias | L-748,337 |
Molecular Weight | 497.61 |
Formula | C26H31N3O5S |
Cas No. | 244192-94-7 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 20 mg/mL (40.19 mM) DMSO: 80 mg/mL (160.77 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
DMSO
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