Shopping Cart
- Remove All
Your shopping cart is currently empty
Lenumlostat
🥰Excellent
Catalog No. T69913Cas No. 2098884-52-5
Alias PAT-1251, GB2064
Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.
Lenumlostat
🥰Excellent
Purity: 99.88%
Catalog No. T69913Alias PAT-1251, GB2064Cas No. 2098884-52-5
Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $197 | In Stock | |
| 5 mg | $497 | In Stock | |
| 10 mg | $747 | In Stock | |
| 25 mg | $1,490 | In Stock | |
| 50 mg | $2,320 | In Stock | |
| 100 mg | $3,320 | In Stock | |
| 500 mg | $6,670 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $547 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Lenumlostat"
Paeonol
Peonol
T2900552-41-0
Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
- $46
Size
QTY
Methylene Blue trihydrate
Methylthionine chloride, Methylene Blue, Basic blue 9
T00067220-79-3
Methylene Blue trihydrate (Basic blue 9) is a compound consisting of dark green crystals or crystalline powder, having a bronze-like luster. Solutions in water or alcohol have a deep blue color. Methylene Blue trihydrate is used as a bacteriologic stain and as an indicator. It inhibits soluble guanylyl cyclase and has been used to treat cyanide poisoning and to lower levels of methemoglobin. It also inhibits tau filament formation (IC50: 1.9μM).
- $42
Size
QTY
Azure B
Azure B chloride
T18918531-55-5
Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B).
- $128
Size
QTY
Isatin
Pseudoisatin, Indoline-2,3-dione, 2,3-Indolinedione
T686291-56-5
Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor.
- $29
Size
QTY
Methylene Blue
Cited
Tetramethylthionine chloride, methylthioninium chloride, CI-52015, Basic Blue 9
T688861-73-4
Methylene Blue (Tetramethylthionine chloride) (IC50 of 1.9 μM) inhibits tau filament formation. And it inhibits soluble guanylyl cyclase. It is also used as a dye in chromoendoscopy.
- $30
Size
QTY
CitedRosmarinic acid Cited
Rosemary acid, Labiatenic acid
T276520283-92-5
Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and COMT with IC50 of 50.1, 184.6, and 26.7 μM respectively.
- Inquiry Price
Size
QTY
CitedPargyline hydrochloride
Pargylamine hydrochloride
T1578306-07-0
Pargyline hydrochloride (Pargylamine hydrochloride) is an irreversible monoamine oxidase(MAO) inhibitor with antihypertensive properties.
- $30
Size
QTY
Phenelzine sulfate
T12441156-51-4
Phenelzine sulfate is a non-selective, irreversible monoamine oxidase inhibitor (MAOI) with antidepressant and anxiolytic properties.
- $31
Size
QTY
Norharmane
β-Carboline, 2-Azacarbazole, 2,9-Diazafluorene
T4024244-63-3
Norharmane (β-Carboline) is a natural β-carboline first isolated from plants of the Zygophyllaceae family.
- $30
Size
QTY
J-147 Cited
J147
T19931146963-51-0
J-147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging. It is a curcumin derivative and a potent neurogenic and neuroprotective drug candidate initially developed for the treatment of neurodegenerative conditions associated with aging that impacts many pathways implicated in the pathogenesis of diabetic neuropathy.
- $40
Size
QTY
CitedIproniazid Phosphate
Isoproniazid phosphate
T0821305-33-9
Iproniazid Phosphate is a non-selective, irreversible monoamine oxidase inhibitor (MAOI).
- $29
Size
QTY
Bifemelane hydrochloride
T2260562232-46-6
Bifemelane hydrochloride is a MAO inhibitor
- $35
Size
QTY
Select Batch
Purity:99.88%
ee:100%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lenumlostat is an orally available, selective and potent lysyl oxidase-like protein 2 (LOXL2) inhibitor with inhibitory effects on hLOXL2, hLOXL3 and LOXL2 for the study of fibrotic diseases. |
| Targets&IC50 | LOXL2:0.10 μM (Mouse), LOXL3 (human):1.17 μM, LOXL2 (human):0.71 μM, LOXL2:0.12 μM (Rat), LOXL2:0.16 μM (Dog) |
| In vitro | Lenumlostat(PAT-1251)is a Lysyl Oxidase-Like 2 (LOXL2) inhibitor, with IC50s of 0.71 μM and 1.17 μM for hLOXL2 and hLOXL3, respectively. It also potently inhibits LOXL2 in mouse, rat, and dog, with IC50s of 0.10 μM, 0.12 μM, and 0.16 μM, respectively. Lenumlostat(PAT-1251) exhibits high selectivity for LOXL2 over other key members of the amine oxidase family, such as the copper-dependent amine oxidases semicarbazide-sensitive amine oxidase (SSAO) and diamine oxidase (DAO). Additionally, it shows selectivity against the flavin-dependent monoamine oxidases A (MAO-A) and B (MAO-B), with less than 10% inhibition at 10 μM[1]. |
| Alias | PAT-1251, GB2064 |
| Molecular Weight | 399.34 |
| Formula | C18H17F4N3O3 |
| Cas No. | 2098884-52-5 |
| Smiles | O(C=1N=C(C(F)(F)F)C=C(CN)C1)C2=CC(C(=O)N3C[C@@H](F)[C@H](O)C3)=CC=C2 |
Storage & Solubility Information
| Storage | store under nitrogen | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (112.69 mM), Sonication is recommended.  H2O: 80 mg/mL (200.33 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO/H2O
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Lenumlostat | purchase Lenumlostat | Lenumlostat cost | order Lenumlostat | Lenumlostat chemical structure | Lenumlostat in vitro | Lenumlostat formula | Lenumlostat molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.