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Licochalcone E

🥰Excellent
Catalog No. TN1055Cas No. 864232-34-8

Licochalcone E is a potential LXRβ agonist.

Licochalcone E

Licochalcone E

🥰Excellent
Purity: 98.09%
Catalog No. TN1055Cas No. 864232-34-8
Licochalcone E is a potential LXRβ agonist.
Pack SizePriceAvailabilityQuantity
1 mg$98In Stock
5 mg$342In Stock
10 mg$548In Stock
25 mg$872In Stock
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Purity:98.09%
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Product Introduction

Bioactivity
Description
Licochalcone E is a potential LXRβ agonist.
In vitro
In this study, the quantitative pharmacophores were constructed by 3D-QSAR pharmacophore (Hypogen) method based on the LXRβ agonists. The optimal pharmacophore model containing one hydrogen bond acceptor, two hydrophobics and one ring aromatic was obtained based on five assessment indictors, including the correlation between predicted value and experimental value of the compounds in training set (correlation), α?cost of the models (α?cost), hit rate of active compounds (HRA), identification of effectiveness index (IEI) and comprehensive evaluation index (CAI). And the values of the five assessment indicators were 0.95, 128.65, 84.44%, 2.58 and 2.18 respectively. The best model as a query to screen the traditional Chinese medicine database (TCMD), a list of 309 compounds was obtained andwere then refined using Libdock program. Finally, based on the screening rules of the Libdock score of initial compound and the key interactions between initial compound and receptor, four compounds, demethoxycurcumin, isolicoflavonol, Licochalcone E and silydianin, were selected as potential LXRβ agonists[1]
Chemical Properties
Molecular Weight338.4
FormulaC21H22O4
Cas No.864232-34-8
SmilesCOc1cc(O)c(cc1\C=C\C(=O)c1ccc(O)cc1)[C@@H](C)C(C)=C
Relative Density.no data available
Storage & Solubility Information
Storagestore at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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