Popular Searches
Diphenyleneiodonium chlorideEpacadostatGilteritinibDinaciclibRo-3306
TargetMol | Star Product
Wikimole
TargetMol | New Product
New Product
TargetMol | Compound Library
Compound Library
Contact Us
Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TOPBioactivityChemical infoStorage&SolubilityCalculator

Lin28-let-7a antagonist 1

🥰Excellent
Catalog No. T11851Cas No. 2024548-03-4

Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction，and shows a clear antagonistic effect against the Lin28-let-7a interaction.

Lin28-let-7a antagonist 1

Lin28-let-7a antagonist 1

🥰Excellent
Purity: 99.91%
Catalog No. T11851Cas No. 2024548-03-4
Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction，and shows a clear antagonistic effect against the Lin28-let-7a interaction.
Pack SizePriceAvailabilityQuantity
1 mg$93In Stock
5 mg$228In Stock
10 mg$347In Stock
25 mg$625In Stock
50 mg$939In Stock
100 mg$1,380In Stock
1 mL x 10 mM (in DMSO)$296In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "Lin28-let-7a antagonist 1"

Select Batch
Purity:99.91%
Contact us for more batch information
Resource Download
COA HPLC HNMR
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
Lin28-let-7a antagonist 1, with an IC50 of 4.03 μM for Lin28A-let-7a-1 interaction,and shows a clear antagonistic effect against the Lin28-let-7a interaction.
Targets&IC50
Lin28A-let-7a-1:4.03 μM
In vitro
When the expression of both Lin28A and Lin28B are knocked-down using siRNA in JAR cells, the Lin28-let-7a antagonist 1-induced increase in cellular let-7 levels is clearly attenuated. Lin28A-let-7a-IN-1 increases mature let-7 levels in PA-1 cells that express high level of Lin28A. On the other hand, let-7 levels are not affected by 1 in MCF7 cells that rarely express Lin28 proteins. Taken together, Lin28-let-7a antagonist 1 specifically induces the increase in the cellular let-7 levels by targeting Lin28.Lin28-let-7a antagonist 1 shows a clear antagonistic effect against the Lin28A-let-7a-1 interaction with an IC50 of 4.03 μM. Interestingly, Lin28-let-7a antagonist 1 also inhibits the Lin28B-let-7 interaction, with slightly reduced potency. Dicer processing assay reveals that Lin28-let-7a antagonist 1 clearly blocks the formation of the Lin28A-pre-let-7g complex and induces miRNA processing, resulting in the generation of mature let-7g miRNA.
Chemical Properties
Molecular Weight583.59
FormulaC31H29N5O7
Cas No.2024548-03-4
SmilesCC1(C)Oc2cc(N3CCN(CC3)C(=O)OCc3ccccc3)c(cc2-c2c1cnn2-c1ccc(cc1)C(O)=O)[N+]([O-])=O
Relative Density.1.42 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/ml (102.81 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7135 mL8.5677 mL17.1353 mL85.6766 mL
5 mM0.3427 mL1.7135 mL3.4271 mL17.1353 mL
10 mM0.1714 mL0.8568 mL1.7135 mL8.5677 mL
20 mM0.0857 mL0.4284 mL0.8568 mL4.2838 mL
50 mM0.0343 mL0.1714 mL0.3427 mL1.7135 mL
100 mM0.0171 mL0.0857 mL0.1714 mL0.8568 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

InhibitorinhibitMicroRNALin-28-let-7a antagonist 1Lin28-let-7a antagonist 1Lin28 let 7a antagonist 1miRNALin28let7a antagonist 1
Related Tags: buy Lin28-let-7a antagonist 1 | purchase Lin28-let-7a antagonist 1 | Lin28-let-7a antagonist 1 cost | order Lin28-let-7a antagonist 1 | Lin28-let-7a antagonist 1 chemical structure | Lin28-let-7a antagonist 1 in vitro | Lin28-let-7a antagonist 1 formula | Lin28-let-7a antagonist 1 molecular weight
TargetMol | Logo

Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.