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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $97 | In Stock | |
10 mg | $173 | In Stock | |
25 mg | $349 | In Stock | |
50 mg | $565 | In Stock | |
1 mL x 10 mM (in DMSO) | $117 | In Stock |
Description | Cl-amidine hydrochloride is an orally active peptidylarginine deiminase (PAD) inhibitor (IC50: 5.9 μM for PAD4) that induces apoptosis in cancer cells, induces microRNA (miR)-16 in vitro causing cell cycle arrest, prevents histone 3 citrullination, and inhibits neutrophil extracellular trap formation, improving survival in a murine sepsis model. |
Targets&IC50 | PAD4:5.9 μM |
In vitro | Cl-amidine, a bioavailable haloacetamidine-based compound, inhibits all the active PAD isozymes with near equal potency (kinact/KI=13,000 M-1 min-1 for PAD4)[1]. The colon cancer cell line (HT29) is relatively resistant to apoptosis caused by Cl-amidine[2]. Cl-amidine (0, 5, 10, 15, 20, 25, 50 μg/mL, 24 hours) induces apoptosis in TK6 lymphoblastoid cells and HT29 colon cancer cells in a dose-dependent manner. |
In vivo | Cl-amidine (5, 25, 75 mg/kg, oral gavage, once daily) causes significant reductions in the histology scores dose-dependently. Cl-amidine (75 mg/kg, ip once daily) inhibits and treats DSS-induced colitis in mice[2]. |
Molecular Weight | 347.24 |
Formula | C14H20Cl2N4O2 |
Cas No. | 1373232-26-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 19.23 mg/mL (55.38 mM), Sonication is recommended. H2O: 50 mg/mL (143.99 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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