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LUF6096

LUF6096
LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. It displays protective effects in myocardial ischemia/reperfusion injury.
Catalog No. T9180Cas No. 1116652-18-6
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Purity:100%
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LUF6096

Purity: 100%
Catalog No. T9180Alias CF-602Cas No. 1116652-18-6

LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. It displays protective effects in myocardial ischemia/reperfusion injury.
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Pack SizePriceAvailabilityQuantity
1 mg$49In Stock
2 mg$73In Stock
5 mg$118In Stock
10 mg$196In Stock
25 mg$334In Stock
50 mg$472In Stock
100 mg$672In Stock
500 mgInquiryIn Stock
1 mL x 10 mM (in DMSO)$135In Stock
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Product Introduction

Bioactivity
Description
LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. It displays protective effects in myocardial ischemia/reperfusion injury.
In vitro
LUF6096 (10 μM; 30-120 min) reduces the dissociation rate of 125I-AB-MECA from the A3 receptor by 2.5 times in CHO cell membranes and, when pretreated for 15 min, significantly enhances the intrinsic activity of Cl-IB-MECA in inhibiting forskolin-stimulated cAMP production in CHO cells[1].
In vivo
LUF6096 (twice i.v. bolus at 0.5 mg/kg or single i.v. bolus at 1 mg/kg) protects against myocardial ischemia/reperfusion injury in dogs[1].
AliasCF-602
Chemical Properties
Molecular Weight414.33
FormulaC22H21Cl2N3O
Cas No.1116652-18-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (96.54 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4135 mL12.0677 mL24.1354 mL120.6768 mL
5 mM0.4827 mL2.4135 mL4.8271 mL24.1354 mL
10 mM0.2414 mL1.2068 mL2.4135 mL12.0677 mL
20 mM0.1207 mL0.6034 mL1.2068 mL6.0338 mL
50 mM0.0483 mL0.2414 mL0.4827 mL2.4135 mL

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