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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $49 | In Stock | |
2 mg | $73 | In Stock | |
5 mg | $118 | In Stock | |
10 mg | $196 | In Stock | |
25 mg | $334 | In Stock | |
50 mg | $472 | In Stock | |
100 mg | $672 | In Stock | |
500 mg | Inquiry | In Stock | |
1 mL x 10 mM (in DMSO) | $135 | In Stock |
Description | LUF6096 (CF-602) is a potent allosteric enhancer of the adenosine A3 receptor, exhibiting the capability to enhance agonist binding allosterically while demonstrating low orthosteric affinity across adenosine receptors. It displays protective effects in myocardial ischemia/reperfusion injury. |
In vitro | LUF6096 (10 μM; 30-120 min) reduces the dissociation rate of 125I-AB-MECA from the A3 receptor by 2.5 times in CHO cell membranes and, when pretreated for 15 min, significantly enhances the intrinsic activity of Cl-IB-MECA in inhibiting forskolin-stimulated cAMP production in CHO cells[1]. |
In vivo | LUF6096 (twice i.v. bolus at 0.5 mg/kg or single i.v. bolus at 1 mg/kg) protects against myocardial ischemia/reperfusion injury in dogs[1]. |
Alias | CF-602 |
Molecular Weight | 414.33 |
Formula | C22H21Cl2N3O |
Cas No. | 1116652-18-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (96.54 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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