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Lupeol acetate
🥰Excellent
Catalog No. TN1890Cas No. 1617-68-1
Alias Lupeyl acetate, 3-Acetyllupeol
Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells.
Lupeol acetate
🥰Excellent
Purity: 99.84%
Catalog No. TN1890Alias Lupeyl acetate, 3-AcetyllupeolCas No. 1617-68-1
Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $71 | In Stock | |
| 5 mg | $172 | In Stock | |
| 10 mg | $277 | In Stock | |
| 25 mg | $469 | In Stock | |
| 50 mg | $673 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $198 | In Stock |
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CitedSelect Batch
Purity:99.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lupeol acetate is a derivative of Lupeol with anti-cancer, anti-inflammatory, anti-diabetic, anti-snake venom, anti-fertility effects and oral activity. It is able to inhibit rheumatoid arthritis by down-regulating inflammatory cytokines (TNF-α, IL-1β, MCP-1, COX-2, VEGF, granzyme B) and is cytotoxic to Hep-3B and A549 cells. |
| In vitro | Methods: Lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and bone marrow-derived macrophages (BMDM) were treated with Lupeol acetate (0-80μM) and TNF-α, IL-1β, COX-2, and MCP-1 were measured using Western blotting. In addition, bone formation was examined using reverse transcription-PCR (RT-PCR) and tartrate-resistant acid phosphatase (TRAP) staining. Results: Lupeol acetate inhibited the activation, migration, and formation of macrophage osteoclastogenesis in a dose-dependent manner. [3] |
| In vivo | Methods: DBA/1J mice with collagen-induced arthritis (CIA) were randomly divided into three groups: vehicle, Lupeol acetate-treated (50mg/kg), and curcumin-treated (100mg/kg). The therapeutic effects were determined by clinical scores, expression levels of serum cytokines including TNF-α and IL-1β, (18)F-fluorodeoxyglucose ((18)F-FDG) microPET/CT, and histopathology. Results: In RA-bearing mice, the expression of inflammatory-related cytokines was suppressed, and LA improved clinical symptoms and bone erosion. Lupeol acetate also significantly reduced the accumulation of (18)F-FDG in the joints of RA-bearing mice. Lupeol acetate significantly improved the symptoms of RA by downregulating the expression of inflammatory cytokines and osteoclastogenesis. [3] |
| Alias | Lupeyl acetate, 3-Acetyllupeol |
| Molecular Weight | 468.75 |
| Formula | C32H52O2 |
| Cas No. | 1617-68-1 |
| Smiles | C[C@]12[C@@]([C@@]3([C@@](C)(CC1)CC[C@H]3C(C)=C)[H])(CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](OC(C)=O)C5(C)C)[H])[H])[H] |
| Relative Density. | 1.01g/cm3 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | Ethanol: 1 mg/mL (2.13 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
Ethanol
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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