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Macranthoside B

🥰Excellent
Catalog No. T5787Cas No. 146100-02-9

Macranthoside B Iis a natural product isolated from Flos Lonicerae, possesses anti-bacterial activity.

Macranthoside B

Macranthoside B

🥰Excellent
Purity: 98.07%
Catalog No. T5787Cas No. 146100-02-9
Macranthoside B Iis a natural product isolated from Flos Lonicerae, possesses anti-bacterial activity.
Pack SizePriceAvailabilityQuantity
1 mg$46In Stock
5 mg$98In Stock
10 mg$150In Stock
25 mg$249In Stock
50 mg$369In Stock
100 mg$548In Stock
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Purity:98.07%
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Product Introduction

Bioactivity
Description
Macranthoside B Iis a natural product isolated from Flos Lonicerae, possesses anti-bacterial activity.
In vitro
Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo[1].
Cell Research
The anticancer effect of Macranthoside B both in vitro and in vivo using cell proliferation assays and xenograft tumor growth assays. Macranthoside B inhibits the proliferation of various kinds of cancer cells with IC(50) values in the range of 10-20 microM. Moreover, the volume and weight of xenograft tumors in nude mice treated with 5mg/kgMacranthoside B were decreased remarkably compared to those of the vehicle control group. Furthermore, DAPI staining and flow cytometry analysis with Annexin V/PI double staining revealed that more apoptotic cells were observed following Macranthoside B treatment. In addition, degradation of PARP (poly-ADP-ribose polymerase), and activation of the caspase cascade for intrinsic pathways were observed. The expression of Bcl-2 protein decreased and the protein level of Bax increased which leading to an increase of the Bax/Bcl-2 ratio. Macranthoside B exhibited strong anti-tumor effect and mitochondrion-mediated apoptosis induction involved in it[1].
Chemical Properties
Molecular Weight1075.24
FormulaC53H86O22
Cas No.146100-02-9
SmilesC[C@]12C([C@]3([C@@](C(O)=O)(CC1)CCC(C)(C)C3)[H])=CC[C@]4([C@@]2(C)CC[C@@]5([C@]4(C)CC[C@H](O[C@H]6[C@H](O[C@H]7[C@H](O)[C@H](O[C@@H]8O[C@H](CO)[C@@H](O[C@@H]9O[C@H](CO)[C@@H](O)[C@H](O)[C@H]9O)[C@H](O)[C@H]8O)[C@@H](O)[C@H](C)O7)[C@@H](O)[C@@H](O)CO6)[C@]5(CO)C)[H])[H]
Relative Density.1.46 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: <1 mg/mL (insoluble)
DMSO: 50 mg/mL (46.5 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.9300 mL4.6501 mL9.3002 mL46.5012 mL
5 mM0.1860 mL0.9300 mL1.8600 mL9.3002 mL
10 mM0.0930 mL0.4650 mL0.9300 mL4.6501 mL
20 mM0.0465 mL0.2325 mL0.4650 mL2.3251 mL

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