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Macranthoside B
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Macranthoside B
Catalog No. T5787Cas No. 146100-02-9
Macranthoside B Iis a natural product isolated from Flos Lonicerae, possesses anti-bacterial activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $46 | In Stock | |
| 5 mg | $98 | In Stock | |
| 10 mg | $150 | In Stock | |
| 25 mg | $249 | In Stock | |
| 50 mg | $369 | In Stock | |
| 100 mg | $548 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Macranthoside B Iis a natural product isolated from Flos Lonicerae, possesses anti-bacterial activity. |
| In vitro | Macranthoside B, a hederagenin saponin extracted from Lonicera macranthoides and its anti-tumor activities in vitro and in vivo[1]. |
| Cell Research | The anticancer effect of Macranthoside B both in vitro and in vivo using cell proliferation assays and xenograft tumor growth assays. Macranthoside B inhibits the proliferation of various kinds of cancer cells with IC(50) values in the range of 10-20 microM. Moreover, the volume and weight of xenograft tumors in nude mice treated with 5mg/kgMacranthoside B were decreased remarkably compared to those of the vehicle control group. Furthermore, DAPI staining and flow cytometry analysis with Annexin V/PI double staining revealed that more apoptotic cells were observed following Macranthoside B treatment. In addition, degradation of PARP (poly-ADP-ribose polymerase), and activation of the caspase cascade for intrinsic pathways were observed. The expression of Bcl-2 protein decreased and the protein level of Bax increased which leading to an increase of the Bax/Bcl-2 ratio. Macranthoside B exhibited strong anti-tumor effect and mitochondrion-mediated apoptosis induction involved in it[1]. |
| Molecular Weight | 1075.24 |
| Formula | C53H86O22 |
| Cas No. | 146100-02-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||
| Solubility Information | DMSO: 10.75 mg/ml(10 mM)  | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
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