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MSC-4381

Catalog No. T37824Cas No. 2445185-57-7

MSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma.

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Pack Size	Price	Availability
1 mg	$168	In Stock
2 mg	$249	In Stock
5 mg	$419	In Stock
10 mg	$679	In Stock
25 mg	$1,390	In Stock
50 mg	$2,190	In Stock
100 mg	$2,970	In Stock
1 mL x 10 mM (in DMSO)	$463	In Stock

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Product Introduction

Bioactivity

Description	MSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma.
In vitro	MCT4-IN-1 (compound 18n) inhibits lactate efflux in the MDA-MB-231 cell line with an IC50 of 1 nM. On-target activity was confirmed by fluorescence cross correlation spectroscopy (FCCS)[1] with a Ki of 11 nM[1].
In vivo	When MCT4-IN-1 (30 mg/kg; oral; single dose) was used only in combination with MCT1/2 inhibitors, lactic acid accumulation in tumor cells was significant; MCT4-IN-1 (30 mg/kg/day; for 15 consecutive days) had no significant antitumor activity; MCT4-IN-1 (0.2 mg/kg; intravenous injection) had a T1/2 of 1 hour, a CL of 0.33 L/hkg, a Cmax of 489 ng/mL, and a Vss of 0.4 L/kg in mice[1].
Alias	MCT4-IN-1, MSC 4381, MSC4381

Chemical Properties

Molecular Weight	537.97
Formula	C26H20ClN3O6S
Cas No.	2445185-57-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (92.94 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8588 mL	9.2942 mL	18.5884 mL	92.9420 mL
5 mM	0.3718 mL	1.8588 mL	3.7177 mL	18.5884 mL
10 mM	0.1859 mL	0.9294 mL	1.8588 mL	9.2942 mL
20 mM	0.0929 mL	0.4647 mL	0.9294 mL	4.6471 mL
50 mM	0.0372 mL	0.1859 mL	0.3718 mL	1.8588 mL

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Keywords

MCT-4-IN-1MCT4IN1MCT4 IN 1

MSC-4381

MSC-4381

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