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MSC-4381
🥰Excellent
Catalog No. T37824Cas No. 2445185-57-7
Alias MSC4381, MSC 4381, MCT4-IN-1
MSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma.
MSC-4381
🥰Excellent
Purity: 99.04%
Catalog No. T37824Alias MSC4381, MSC 4381, MCT4-IN-1Cas No. 2445185-57-7
MSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $64 | In Stock | |
| 5 mg | $156 | In Stock | |
| 10 mg | $239 | In Stock | |
| 25 mg | $413 | In Stock | |
| 50 mg | $579 | In Stock | |
| 100 mg | $828 | In Stock | |
| 200 mg | $1,090 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $185 | In Stock |
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Purity:99.04%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | MSC-4381 (MCT4-IN-1) is an orally available and selectively modeled highly potent inhibitor of monocarboxylic acid transporter protein 4 (MCT4/SLC16A3) with potential anticancer and antitumor activity for the study of osteosarcoma. |
| In vitro | MCT4-IN-1 (compound 18n) inhibits lactate efflux in the MDA-MB-231 cell line with an IC50 of 1 nM. On-target activity was confirmed by fluorescence cross correlation spectroscopy (FCCS)[1] with a Ki of 11 nM[1]. |
| In vivo | When MCT4-IN-1 (30 mg/kg; oral; single dose) was used only in combination with MCT1/2 inhibitors, lactic acid accumulation in tumor cells was significant; MCT4-IN-1 (30 mg/kg/day; for 15 consecutive days) had no significant antitumor activity; MCT4-IN-1 (0.2 mg/kg; intravenous injection) had a T1/2 of 1 hour, a CL of 0.33 L/hkg, a Cmax of 489 ng/mL, and a Vss of 0.4 L/kg in mice[1]. |
| Alias | MSC4381, MSC 4381, MCT4-IN-1 |
| Molecular Weight | 537.97 |
| Formula | C26H20ClN3O6S |
| Cas No. | 2445185-57-7 |
| Smiles | CCOc1ccc(c2ncccc12)S(=O)(=O)Nc1ccc(Cl)cc1C#Cc1cnc(cc1OC)C(O)=O |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (92.94 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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