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MCT1-IN-3

🥰Excellent
Catalog No. T67727Cas No. 2878360-80-4

MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm and also exhibits significant inhibitory activity against the multidrug transporter ABCB1.

MCT1-IN-3

MCT1-IN-3

🥰Excellent
Purity: 98.87%
Catalog No. T67727Cas No. 2878360-80-4
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm and also exhibits significant inhibitory activity against the multidrug transporter ABCB1.
Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
5 mg$268In Stock
10 mg$395In Stock
25 mg$592In Stock
50 mg$828In Stock
100 mg$1,130In Stock
500 mg$2,270In Stock
1 mL x 10 mM (in DMSO)$287In Stock
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Purity:98.87%
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Product Introduction

Bioactivity
Description
MCT1-IN-3 is a monocarboxylate transporter 1 (MCT1) inhibitor, targeting solute carrier (SLC) monocarboxylate transporter 1 (MCT1; SLC16A1) for cancer treatment. MCT1-IN-3 (compound 24) showed the highest MCT1 transport inhibition with an IC50 value of 81.0 Nm and also exhibits significant inhibitory activity against the multidrug transporter ABCB1.
Targets&IC50
MCT1:81nM
In vitro
MCT1-IN-3 has great antiproliferative activities against the MCT1-expressing cancer cell lines A-549 and MCF-7 with GI50 values of 20 μM and 15.1 μM, respectively. Treatment with MCT1-IN-3 5μM for 24 h significantly leads to cancer cell cycle arrest as well as apoptosis, which has also significant inhibitory power against the multidrug transporter ABCB1 and shows to reverse ABCB1-mediated multidrug resistance (MDR)[1].
Chemical Properties
Molecular Weight389.4
FormulaC22H19N3O4
Cas No.2878360-80-4
SmilesC(=C(C(OC)=O)C#N)C=1C=2C(N(CC(NC3=CC=C(OC)C=C3)=O)C1)=CC=CC2
Relative Density.1.22 g/cm3 (Predicted)
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 22.5 mg/mL (57.78 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5681 mL12.8403 mL25.6805 mL128.4027 mL
5 mM0.5136 mL2.5681 mL5.1361 mL25.6805 mL
10 mM0.2568 mL1.2840 mL2.5681 mL12.8403 mL
20 mM0.1284 mL0.6420 mL1.2840 mL6.4201 mL
50 mM0.0514 mL0.2568 mL0.5136 mL2.5681 mL

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