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AR-C155858

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Purity:98.84%

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COA LCMS HNMR

AR-C155858

Catalog No. T14316Cas No. 496791-37-8

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).

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Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$297	In Stock
10 mg	$517	In Stock
25 mg	$843	In Stock
50 mg	$1,160	In Stock
100 mg	$1,570	In Stock
1 mL x 10 mM (in DMSO)	$312	In Stock

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Product Introduction

Bioactivity

Description

AR-C155858 is an inhibitor of monocarboxylate transporter MCT1 and MCT2 (Kis: 2.3 nM and 10 nM).

In vitro

AR-C155858, at concentrations ranging from 10 nM to 100 nM, effectively inhibits the activity of MCT1/MCT2 C-terminal chimeras[1]. This compound also demonstrates time- and concentration-dependent inhibition of MCT1 when expressed in Xenopus oocytes[2]. Furthermore, AR-C155858 exhibits an inhibitory effect on MCT2, achieving 70% inhibition at 10 nM, with inhibition levels increasing gradually, indicative of a dissociation constant (Ki) value significantly lower than 10 nM.

Chemical Properties

Molecular Weight	461.53
Formula	C21H27N5O5S
Cas No.	496791-37-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (86.67 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1667 mL	10.8335 mL	21.6671 mL	108.3353 mL
5 mM	0.4333 mL	2.1667 mL	4.3334 mL	21.6671 mL
10 mM	0.2167 mL	1.0834 mL	2.1667 mL	10.8335 mL
20 mM	0.1083 mL	0.5417 mL	1.0834 mL	5.4168 mL
50 mM	0.0433 mL	0.2167 mL	0.4333 mL	2.1667 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc