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Methoxyamine HCl

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COA HNMR

Methoxyamine HCl

Catalog No. T21320Cas No. 593-56-6

Methoxyamine HCl (Methoxyamine) covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. This agent may potentiate the anti-tumor activity of alkylating agents.

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Pack Size	Price	Availability	Quantity
5 g	$42	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock

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Product Introduction

Bioactivity

Description	Methoxyamine HCl (Methoxyamine) covalently binds to apurinic/apyrimidinic (AP) DNA damage sites and inhibits base excision repair (BER), which may result in an increase in DNA strand breaks and apoptosis. Methoxyamine is an orally bioavailable small molecule inhibitor with potential adjuvant activity. This agent may potentiate the anti-tumor activity of alkylating agents.
Alias	TRC102, TRC 102, Methoxyamine, TRC-102

Chemical Properties

Molecular Weight	83.51
Formula	CH6ClNO
Cas No.	593-56-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: Soluble

DMSO: 55 mg/ml (658.6 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	11.9746 mL	59.8731 mL	119.7461 mL	598.7307 mL
5 mM	2.3949 mL	11.9746 mL	23.9492 mL	119.7461 mL
10 mM	1.1975 mL	5.9873 mL	11.9746 mL	59.8731 mL
20 mM	0.5987 mL	2.9937 mL	5.9873 mL	29.9365 mL
50 mM	0.2395 mL	1.1975 mL	2.3949 mL	11.9746 mL
100 mM	0.1197 mL	0.5987 mL	1.1975 mL	5.9873 mL

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In Vivo Formulation Calculator (Clear solution)

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Keywords

Methoxyamine HCl