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ML266

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Catalog No. T8990Cas No. 1462267-08-8

ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 µM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function. This compound shows promise for Gaucher disease research.

ML266

ML266

🥰Excellent
Purity: 98.45%
Catalog No. T8990Cas No. 1462267-08-8
ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 µM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function. This compound shows promise for Gaucher disease research.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
2 mg$68In Stock
5 mg$113In Stock
10 mg$178In Stock
25 mg$362In Stock
50 mg$498In Stock
100 mg$725In Stock
500 mg$1,520In Stock
1 mL x 10 mM (in DMSO)$123In Stock
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Purity:98.45%
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Product Introduction

Bioactivity
Description
ML266, a glucocerebrosidase (GCase) chaperone with an IC50 of 2.5 µM, facilitates the transport of the mutant protein to the lysosome, thereby restoring GCase activity without inhibiting the enzyme's function. This compound shows promise for Gaucher disease research.
Chemical Properties
Molecular Weight496.35
FormulaC24H22BrN3O4
Cas No.1462267-08-8
SmilesCN(C(=O)CNC(=O)c1ccccc1OCC(=O)Nc1ccc(Br)cc1)c1ccccc1
Relative Density.1.445 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 45 mg/mL (90.66 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0147 mL10.0735 mL20.1471 mL100.7354 mL
5 mM0.4029 mL2.0147 mL4.0294 mL20.1471 mL
10 mM0.2015 mL1.0074 mL2.0147 mL10.0735 mL
20 mM0.1007 mL0.5037 mL1.0074 mL5.0368 mL
50 mM0.0403 mL0.2015 mL0.4029 mL2.0147 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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