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MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $187 | In Stock | |
5 mg | $397 | In Stock | |
10 mg | $597 | In Stock | |
25 mg | $953 | In Stock | |
50 mg | $1,290 | In Stock | |
100 mg | $1,730 | In Stock |
Description | MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM). |
Targets&IC50 | ACE2 (human):0.44 nM (IC50), Carboxypeptidase A (bovine):27 μM (IC50) |
In vitro | MLN-4760 displays pIC50 at rhACE2 of 8.5±0.1 and at rhACE of 4.4±0.2. MLN-4760 also shows pIC50 at rhACE2 of 4.7±0.1, 6.9±0.1, and an ACE of 4.4±0.1, 6.2±0.1 in murine heart and mononuclear cells (MNCs), respectively. MLN-4760 potently quenches the cleavage of the 7-Mca-YVADAPK(Dnp) in rhACE2[2]. |
In vivo | MLN-4760 (100 μM, intracerebroventricular infusion for five days) significantly exacerbates neurological function at 4 hours and 3 days post-stroke, without a notable increase in infarct volume[3]. |
Molecular Weight | 428.31 |
Formula | C19H23Cl2N3O4 |
Cas No. | 305335-31-3 |
Smiles | CC(C)C[C@H](N[C@@H](Cc1cncn1Cc1cc(Cl)cc(Cl)c1)C(O)=O)C(O)=O |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | H2O: < 1 mg/mL(insoluble or slightly soluble), Sonication is recommended. |
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