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MLN-4760

Catalog No. T16116Cas No. 305335-31-3

MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).

MLN-4760

MLN-4760

Purity: 99.05%
Catalog No. T16116Cas No. 305335-31-3
MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
Pack SizePriceAvailabilityQuantity
1 mg$187In Stock
5 mg$397In Stock
10 mg$597In Stock
25 mg$953In Stock
50 mg$1,290In Stock
100 mg$1,730In Stock
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Purity:99.05%
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Product Introduction

Bioactivity
Description
MLN-4760 is an angiotensin-converting (ACE2) inhibitor(human ACE2;IC50=0.44 nM). It also has excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
Targets&IC50
ACE2 (human):0.44 nM (IC50), Carboxypeptidase A (bovine):27 μM (IC50)
In vitro
MLN-4760 displays pIC50 at rhACE2 of 8.5±0.1 and at rhACE of 4.4±0.2. MLN-4760 also shows pIC50 at rhACE2 of 4.7±0.1, 6.9±0.1, and an ACE of 4.4±0.1, 6.2±0.1 in murine heart and mononuclear cells (MNCs), respectively. MLN-4760 potently quenches the cleavage of the 7-Mca-YVADAPK(Dnp) in rhACE2[2].
In vivo
MLN-4760 (100 μM, intracerebroventricular infusion for five days) significantly exacerbates neurological function at 4 hours and 3 days post-stroke, without a notable increase in infarct volume[3].
Chemical Properties
Molecular Weight428.31
FormulaC19H23Cl2N3O4
Cas No.305335-31-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 199 mg/mL (464.62 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3348 mL11.6738 mL23.3476 mL116.7379 mL
5 mM0.4670 mL2.3348 mL4.6695 mL23.3476 mL
10 mM0.2335 mL1.1674 mL2.3348 mL11.6738 mL
20 mM0.1167 mL0.5837 mL1.1674 mL5.8369 mL
50 mM0.0467 mL0.2335 mL0.4670 mL2.3348 mL
100 mM0.0233 mL0.1167 mL0.2335 mL1.1674 mL

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