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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $57 | In Stock | |
10 mg | $86 | In Stock | |
25 mg | $131 | In Stock |
Description | MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji (5T4-) cell lines, respectively. MMAF-Ome is also an ADC cytotoxin. |
In vitro | 2.5F-Fc and 2.5F-Fc-MMAF have similar IC50 values (6.9±1.1 vs. 8.3±1.3 nM, respectively)[1]. MMAF conjugation has negligible impact on integrin-binding affinity[1]. |
Alias | Monomethyl auristatin F methyl ester |
Molecular Weight | 745.99 |
Formula | C40H67N5O8 |
Cas No. | 863971-12-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | 5% DMSO+95% Saline: 4 mg/mL (5.36 mM) ![]() DMSO: 99 mg/mL (132.70 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/5% DMSO+95% Saline
DMSO
|
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