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MS-444
Catalog No. T16145Cas No. 150045-18-4
Alias MS444, BE-34776, BE34776
MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.
MS-444
Catalog No. T16145Alias MS444, BE-34776, BE34776Cas No. 150045-18-4
MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $624 | In Stock | |
| 2 mg | $865 | In Stock | |
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Purity:99.45%
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Product Introduction
Bioactivity
Chemical Properties
| Description | MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer. |
| Targets&IC50 | HCA-7 cells:12.84 μM, YAMC cells:28.16 μM, SW480 cells:10.98 μM, RKO cells:5.60 μM, HT-29 cells:14.21 μM, HCT116 cells:10.98 μM, RIE-1 cells:40.70 μM |
| In vitro | MS-444 is a small molecule RNA-binding protein HuR (ELAVL1) inhibitor. Colorectal cancer (CRC) cells that show HuR overexpression are treated with MS-444 (1-100 μM) for 48 hr (HCT116 IC50=10.98 μM, HCA-7 IC50=12.84 μM, RKO IC50=5.60 μM, HT-29 IC50=14.21 μM, and SW480 IC50=10.98 μM). Contrasting effects are observed using non-transformed small intestinal (RIE-1 IC50=40.70 μM) and colonic epithelial cells (YAMC IC50=28.16 μM). [1] |
| In vivo | Mice bearing HCT116 cell xenografts receive intraperitoneal injections of MS-444 (25 mg/kg) or vehicle every 48 hr to test the effects of MS-444 on CRC cell growth in vivo. Anti-tumor effects of MS-444 are observed with an approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 shows a marked 2- to 3-fold reduction in microvessel density (MVD), showing the anti-angiogenic potential of MS-444. [1] |
| Alias | MS444, BE-34776, BE34776 |
| Molecular Weight | 230.22 |
| Formula | C13H10O4 |
| Cas No. | 150045-18-4 |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (173.75 mM.), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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