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MS-444

Name: MS-444
Brand: TargetMol
SKU: T16145
Price: 624 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16145Cas No. 150045-18-4

Alias MS444, BE-34776, BE34776

MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.

MS-444

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Purity: 99.45%

Catalog No. T16145Alias MS444, BE-34776, BE34776Cas No. 150045-18-4

MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.

Pack Size	Price	Availability
1 mg	$624	In Stock
2 mg	$865	In Stock
25 mg	$1,820	8-10 weeks
50 mg	$2,380	8-10 weeks
100 mg	$3,100	8-10 weeks

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Purity:99.45%

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COA

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity

Description	MS-444 (BE-34776) is a smooth muscle myosin light chain kinase (MLCK) and HuR inhibitor with antitumor activity for triple-negative breast and colorectal cancer.
Targets&IC50	RIE-1 cells:40.70 μM, YAMC cells:28.16 μM, RKO cells:5.60 μM, SW480 cells:10.98 μM, HT-29 cells:14.21 μM, HCA-7 cells:12.84 μM, HCT116 cells:10.98 μM
In vitro	MS-444 is a small molecule RNA-binding protein HuR (ELAVL1) inhibitor. Colorectal cancer (CRC) cells that show HuR overexpression are treated with MS-444 (1-100 μM) for 48 hr (HCT116 IC50=10.98 μM, HCA-7 IC50=12.84 μM, RKO IC50=5.60 μM, HT-29 IC50=14.21 μM, and SW480 IC50=10.98 μM). Contrasting effects are observed using non-transformed small intestinal (RIE-1 IC50=40.70 μM) and colonic epithelial cells (YAMC IC50=28.16 μM). [1]
In vivo	Mice bearing HCT116 cell xenografts receive intraperitoneal injections of MS-444 (25 mg/kg) or vehicle every 48 hr to test the effects of MS-444 on CRC cell growth in vivo. Anti-tumor effects of MS-444 are observed with an approximately 1.7-fold reduction in tumor size. Mice treated with MS-444 shows a marked 2- to 3-fold reduction in microvessel density (MVD), showing the anti-angiogenic potential of MS-444. [1]
Alias	MS444, BE-34776, BE34776

Chemical Properties

Molecular Weight	230.22
Formula	C₁₃H₁₀O₄
Cas No.	150045-18-4
Smiles	O=C1C=2C(O)=CC=C(O)C2CC3=COC(=C13)C
Relative Density.	1.452g/cm3

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 40 mg/mL (173.75 mM.), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3437 mL	21.7184 mL	43.4367 mL	217.1836 mL
5 mM	0.8687 mL	4.3437 mL	8.6873 mL	43.4367 mL
10 mM	0.4344 mL	2.1718 mL	4.3437 mL	21.7184 mL
20 mM	0.2172 mL	1.0859 mL	2.1718 mL	10.8592 mL
50 mM	0.0869 mL	0.4344 mL	0.8687 mL	4.3437 mL
100 mM	0.0434 mL	0.2172 mL	0.4344 mL	2.1718 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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