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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $42 | In Stock | |
5 mg | $68 | In Stock | |
10 mg | $98 | In Stock | |
25 mg | $198 | In Stock | |
50 mg | $312 | In Stock | |
100 mg | $531 | In Stock | |
1 mL x 10 mM (in DMSO) | $75 | In Stock |
Description | MS402 is a novel BD1-selective BET BrD inhibitor. |
In vitro | MS402 preferentially renders Brd4 binding to Th17 signature gene loci over those of housekeeping genes and reduces Brd4 recruitment of p-TEFb to phosphorylate and activate RNA polymerase II for transcription elongation. Show that MS402 prevents and ameliorates T-cell transfer-induced colitis in mice by blocking Th17 cell overdevelopment. |
Molecular Weight | 370.83 |
Formula | C20H19ClN2O3 |
Cas No. | 1672684-68-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 22.5 mg/mL (60.67 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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