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MYLS22

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Purity:99.46%

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COA HNMR HPLC

MYLS22

Catalog No. T9127Cas No. 306959-01-3

MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression. It with anti-angiogenesis and anti-cancer activity.

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Pack Size	Price	Availability
2 mg	$35	In Stock
5 mg	$57	In Stock
10 mg	$97	In Stock
25 mg	$166	In Stock
50 mg	$253	In Stock
100 mg	$391	In Stock
200 mg	$587	In Stock
500 mg	$929	In Stock
1 mL x 10 mM (in DMSO)	$63	In Stock

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Product Introduction

Bioactivity

Description	MYLS22 is a first-in-class and selective inhibitor of optic atrophy 1 (OPA1) . MYLS22 can target endothelial OPA1 to curtail tumor growth and inhibits angiogenesis by impinging on NFkB activity and on angiogenic gene expression. It with anti-angiogenesis and anti-cancer activity.
In vivo	MYLS22 (10 mg/kg/die;?peritumoral injection;?every 2 days for 14 days) causes the tumor growth curtailed mice

Chemical Properties

Molecular Weight	443.52
Formula	C24H21N5O2S
Cas No.	306959-01-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (101.46 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2547 mL	11.2734 mL	22.5469 mL	112.7345 mL
5 mM	0.4509 mL	2.2547 mL	4.5094 mL	22.5469 mL
10 mM	0.2255 mL	1.1273 mL	2.2547 mL	11.2734 mL
20 mM	0.1127 mL	0.5637 mL	1.1273 mL	5.6367 mL
50 mM	0.0451 mL	0.2255 mL	0.4509 mL	2.2547 mL
100 mM	0.0225 mL	0.1127 mL	0.2255 mL	1.1273 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OPA1InhibitoropticatrophyMYLS 22endothelialMYLS22inhibittumorMYLS-22