Shopping Cart
- Remove All
Your shopping cart is currently empty
N-type calcium channel blocker-1
Catalog No. T12153Cas No. 241499-17-2
N-type calcium channel blocker-1 is an orally active analgesic agent with a high affinity for functionally blocking N-type calcium channels.
N-type calcium channel blocker-1
Catalog No. T12153Cas No. 241499-17-2
N-type calcium channel blocker-1 is an orally active analgesic agent with a high affinity for functionally blocking N-type calcium channels.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "N-type calcium channel blocker-1"
L-Ascorbic acid
Cited
Vitamin C, L-Ascorbate, L(+)-Ascorbic acid, Ascorbic acid
T092850-81-7
L-Ascorbic acid (Vitamin C) is a natural product that is a potent reducing agent and antioxidant. L-Ascorbic acid functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen. L-Ascorbic acid is used in the treatment of scurvy.
- $42
Size
QTY
Cited1-Octanol
Octanol
T10024111-87-5
1-Octanol, a saturated fatty alcohol, functions as an inhibitor of T-type calcium channels (T-channels), showing an inhibitory concentration (IC50) of 4 μM for native T-currents[1]. Additionally, 1-Octanol is recognized for its potential as a biofuel, possessing diesel-like properties[2].
- $39
Size
QTY
Ethyl cinnamate
TN1624103-36-6
Ethyl cinnamate has antifungal, and vasorelaxant effects. Ethyl cinnamate can lead to the damage of cell membrane system and metabolic disorder through inducing lipid peroxidation via initiating ROS overproduction. Ethyl cinnamate can inhibit the tonic contractions induced by high K+ and phenylephrine (PE) in a concentration-dependent manner, with respective IC50 values of 0.30 mM and 0.38 mM.
- $29
Size
QTY
Nisoldipine Cited
BAY-k 5552
T016363675-72-9
Nisoldipine (BAY-k 5552) is a dihydropyridine calcium channel antagonist that acts as a potent arterial vasodilator and antihypertensive agent.
- $41
Size
QTY
CitedLanthanum(III) chloride heptahydrate
T2235310025-84-0
Lanthanum(III) chloride is an inorganic compound which used in biochemical research to block the activity of divalent cation channels, especially calcium channels.
- $40
Size
QTY
Diltiazem hydrochloride
RG 83606 HCl, Diltiazem HCl, CRD-401
T011233286-22-5
Diltiazem hydrochloride (RG 83606 HCl) is a benzothiazepine calcium channel blocking agent with vasodilating action due to its antagonism of the actions of CALCIUM ion on membrane functions.
- $46
Size
QTY
Levetiracetam
UCB L059, SIB-S1
T0192102767-28-2
Levetiracetam (SIB-S1) is a relatively unique anticonvulsant that is typically used in combination with other antiepileptic medications for partial onset seizures. Levetiracetam has been linked to rare instances of serum aminotransferase and alkaline phosphatase elevations during treatment and to rare cases of clinically apparent drug induced liver disease.
- $50
Size
QTY
Otilonium bromide
SP63, Octylonium bromide
T147426095-59-0
Otilonium bromide (SP63) , an antimuscarinic, is utilized as a spasmolytic agent.
- $31
Size
QTY
Nimodipine Cited
BAY-e 9736
T034366085-59-4
Nimodipine (BAY-e 9736), a 1, 4-dihydropyridine calcium channel blocker, acts primarily on vascular smooth muscle cells.
- $40
Size
QTY
Cited2,5-Di-tert-butylhydroquinone
BHQ
T754088-58-4
2,5-Di-tert-butylhydroquinone (BHQ) is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.
- $29
Size
QTY
1,2,4-Trihydroxybenzene
Benzene-1,2,4-triol
T37705533-73-3
1,2,4-Trihydroxybenzene (Benzene-1,2,4-triol) is a by-product of coffee bean roasting and is found in mouse, arabica coffee.1,2,4-Trihydroxybenzene is a benzotriol that increases Ca2+ concentration in rat thymic lymphocytes.
- $42
Size
QTY
Butamben
Butyl 4-aminobenzoate
T091694-25-7
Butamben (Butyl 4-aminobenzoate) is a long-duration local anesthetic used for the treatment of chronic pain.
- $31
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | N-type calcium channel blocker-1 is an orally active analgesic agent with a high affinity for functionally blocking N-type calcium channels. |
| Targets&IC50 | Ca2+ channel, N-type:0.7 μM |
| In vitro | N-type calcium channel blocker-1, the most orally active compound in its series for analgesia, demonstrates significant activity in the IMR32 assay with an IC50 of 0.7 μM[1]. |
| In vivo | A time course study of N-type calcium channel blocker-1 in the anti-writhing model indicates that the CF-1 mice have maximal effect at 120 min after oral dosing at 60 mg/kg.?Further evaluation of N-type calcium channel blocker-1 demonstrates several important and advantageous features: the pharmacokinetic profile of N-type calcium channel blocker-1 is improved (Versus of 5.9 L/kg and CL of 26 mL/min/kg) and the logPn of 26 is favorable for CNS agent (logPn measured to be 3.20) |
| Molecular Weight | 461.73 |
| Formula | C31H47N3 |
| Cas No. | 241499-17-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy N-type calcium channel blocker-1 | purchase N-type calcium channel blocker-1 | N-type calcium channel blocker-1 cost | order N-type calcium channel blocker-1 | N-type calcium channel blocker-1 chemical structure | N-type calcium channel blocker-1 in vivo | N-type calcium channel blocker-1 in vitro | N-type calcium channel blocker-1 formula | N-type calcium channel blocker-1 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.