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N-type calcium channel blocker-1
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N-type calcium channel blocker-1
Catalog No. T12153Cas No. 241499-17-2
N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | N-type calcium channel blocker-1 is an orally active analgesic agent,shows high affinity to functionally block N-type calcium channels. |
| In vitro | N-type calcium channel blocker-1 is the most orally active blocker of N-type calcium channel for analgesia found in a series of compounds.N-type calcium channel blocker-1 shows good activities in the IMR32 assay with IC50 of 0.7 μM[1]. |
| In vivo | A time course study of N-type calcium channel blocker-1 in the anti-writhing model indicates that the CF-1 mice have maximal effect at 120 min after oral dosing at 60 mg/kg.?Further evaluation of N-type calcium channel blocker-1 demonstrates several important and advantageous features: the pharmacokinetic profile of N-type calcium channel blocker-1 is improved (Versus of 5.9 L/kg and CL of 26 mL/min/kg) and the logPn of 26 is favorable for CNS agent (logPn measured to be 3.20) |
| Molecular Weight | 461.73 |
| Formula | C31H47N3 |
| Cas No. | 241499-17-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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