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Naphthofluorescein
🥰Excellent
Catalog No. T36953Cas No. 61419-02-1
Alias Naphthafluorescein
Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects. Naphthofluorescein is also a fluorescent pH-sensitive probe for functional Cherenkov imaging.
Naphthofluorescein
🥰Excellent
Purity: 99.34%
Catalog No. T36953Alias NaphthafluoresceinCas No. 61419-02-1
Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects. Naphthofluorescein is also a fluorescent pH-sensitive probe for functional Cherenkov imaging.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $44 | In Stock |
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CitedSelect Batch
Purity:99.34%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Naphthofluorescein （Naphthafluorescein） is a Mint3 inhibitor with potential antitumor and anti-inflammatory activities, inhibits the interaction between HIF-1 and Mint3, inhibits Mint3-dependent HIF-1 activity, and inhibits glycolytic activity in cancer cells and macrophages without showing significant in vitro cytotoxicity or in vivo side effects. Naphthofluorescein is also a fluorescent pH-sensitive probe for functional Cherenkov imaging. |
| In vitro | Naphthofluorescein (compound 19) (0-10 μM; 24 h; HT1080 cells) significantly suppresses HIF-1 reporter activity in a concentration-dependent manner.[1] |
| In vivo | Naphthofluorescein (compound 19) (100 mg/kg; i.p.; once daily; 5 days followed by 2 days off for 2 weeks; Male C57BL/6J mice) significantly suppresses tumour growth in subcutaneous E0771 cells and attenuates tumour growth in MDA-MB-231 and AsPC-1 cells in immunodeficient mice. It inhibits tumour growth in human cancer cells in an FIH-1-dependent manner and does not affect FIH-1-depleted MDA-MB-231 cells. No weight loss, histological abnormalities in the lung, liver, and kidney, or severe adverse effects were observed in the mice for at least 2 weeks.[1] |
| Alias | Naphthafluorescein |
| Molecular Weight | 432.42 |
| Formula | C28H16O5 |
| Cas No. | 61419-02-1 |
| Smiles | Oc1ccc2c3Oc4c(ccc5cc(O)ccc45)C4(OC(=O)c5ccccc45)c3ccc2c1 |
| Relative Density. | 1.58 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 2 mg/mL DMSO: 100 mg/mL (231.26 mM), Sonication is recommended. DMF: 10 mg/mL DMF:PBS (pH 7) (1:10): 0.09 mg/mL | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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