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NDT 9513727

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Purity:99.21%

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COA HPLC HNMR

NDT 9513727

Catalog No. T24524Cas No. 439571-48-9

NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$35	In Stock
2 mg	$50	In Stock
5 mg	$81	In Stock
10 mg	$139	In Stock
25 mg	$297	In Stock
50 mg	$496	In Stock
100 mg	$795	In Stock

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Product Introduction

Bioactivity

Description	NDT 9513727 is a potent, selective and competitive C5aR1 inverse agonist for the study of inflammatory and immune disorders.
In vitro	NDT 9513727 inhibited C5a-stimulated responses, including guanosine 5′-3-O-(thio)triphosphate binding, Ca2+ mobilization, oxidative burst, degranulation, cell surface CD11b expression and chemotaxis in various cell types with IC50s from 1.1 to 9.2 nM, respectively[1].
In vivo	NDT 9513727 (3-30 mg/kg) effectively inhibited C5a-induced neutropenia in gerbil and cynomolgus macaque in vivo[1].
Alias	NDT9513727, NDT-9513727

Chemical Properties

Molecular Weight	573.68
Formula	C36H35N3O4
Cas No.	439571-48-9

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 30 mg/mL (52.26 mM)

DMSO: 80 mg/mL (139.37 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.7431 mL	8.7157 mL	17.4313 mL	87.1566 mL
5 mM	0.3486 mL	1.7431 mL	3.4863 mL	17.4313 mL
10 mM	0.1743 mL	0.8716 mL	1.7431 mL	8.7157 mL
20 mM	0.0872 mL	0.4358 mL	0.8716 mL	4.3578 mL
50 mM	0.0349 mL	0.1743 mL	0.3486 mL	1.7431 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0174 mL	0.0872 mL	0.1743 mL	0.8716 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc