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NIBR-LTSi
🥰Excellent
Catalog No. T201369
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration both in vitro and in vivo, accelerates liver regeneration in a mouse partial hepatectomy model, and is capable of expanding organoids derived from several mouse and human tissues.
NIBR-LTSi
🥰Excellent
Purity: 99.87%
Catalog No. T201369
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration both in vitro and in vivo, accelerates liver regeneration in a mouse partial hepatectomy model, and is capable of expanding organoids derived from several mouse and human tissues.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $79 | In Stock | |
| 5 mg | $193 | In Stock | |
| 10 mg | $312 | In Stock | |
| 25 mg | $625 | In Stock |
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CitedSelect Batch
Purity:99.87%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration both in vitro and in vivo, accelerates liver regeneration in a mouse partial hepatectomy model, and is capable of expanding organoids derived from several mouse and human tissues. |
| In vitro | Methods: A human 3D skin model was treated with NIBR-LTSi (1, 3, 10 μM, 3 days) to evaluate its proliferative effects. Results: NIBR-LTSi treatment resulted in a dose-dependent increase in keratinocyte proliferation. In addition, NIBR-LTSi-induced YAP signaling impeded the differentiation of human keratinocytes. [1] |
| In vivo | Methods: Mice were treated with NIBR-LTSi (30, 100 mg/kg, oral administration) to study the later stages of liver regeneration. Results: NIBR-LTSi resulted in significant dose-dependent growth of organoids starting 48 hours after initial treatment and showed reduced expression of the mature podocyte marker WT1 and increased serum blood urea nitrogen (BUN) levels. [1] |
| Molecular Weight | 308.38 |
| Formula | C18H20N4O |
| Smiles | C1CNC[C@H](C1)Oc1ccc(Nc2ccnc3[nH]ccc23)cc1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/mL (3.24 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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