Shopping Cart
- Remove All
Your shopping cart is currently empty
OTSSP167 hydrochloride
Catalog No. T21559Cas No. 1431698-10-0
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
OTSSP167 hydrochloride
Catalog No. T21559Cas No. 1431698-10-0
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $34 | In Stock | |
| 2 mg | $48 | In Stock | |
| 5 mg | $80 | In Stock | |
| 10 mg | $122 | In Stock | |
| 25 mg | $198 | In Stock | |
| 50 mg | $372 | In Stock | |
| 100 mg | $556 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $93 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "OTSSP167 hydrochloride"
OTSSP167
Cited
OTS167, MELK inhibitor
T17591431697-89-0
OTSSP167 (OTS167) is an orally available inhibitor of maternal embryonic leucine zipper kinase (MELK) with potential antineoplastic activity.
- $34
Size
QTY
CitedMELK-8a hydrochloride
T119962096992-20-8
MELK-8a hydrochloride is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK, IC50 = 2 nM).
- $35
Size
QTY
MELK-IN-1
Nintedanib Impurity L, MELK inhibitor 17
T119972095596-44-2In house
MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).
- $30
Size
QTY
HTH-01-091
HTH01-091, HTH-01091, HTH 01-091, HTH 01091
T241522000209-42-5In house
HTH-01-091 is a potent and selective maternal embryonic leucine zipper kinase (MELK) inhibitor (IC50: 10.5 nM) that also inhibits PIM1/2/3, RIPK2, DYRK3, smMLCK, and CLK2. It can be used to study breast cancer.
- $296
Size
QTY
NMS-P715
T122371202055-32-0
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
- $72
Size
QTY
MELK-8a Dihydrochloride
T35342
MELK-8a Dihydrochloride is a useful organic compound for research related to life sciences and the catalog number is T35342.
- $502
Size
QTY
JTV-519 hemifumarate
K201 hemifumarate
T117321435938-25-2
JTV-519 hemifumarate,Antiarrhythmic and cardioprotective properties. is a Ca2+-dependent blocker of sarcoplasmic reticulum Ca2+-stimulated ATPase (SERCA) and a partial agonist of ryanodine receptors in striated muscle.
- Inquiry Price
Size
QTY
Antitumor agent-116
T79582
Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for the MELK receptor [1].
- Inquiry Price
Size
QTY
Select Batch
Purity:99.97%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM). |
| Targets&IC50 | MELK:0.41 nM (IC50) |
| In vitro | OTSSP167 is a highly potent MELK inhibitor with IC of 0.41 nM.?OTSSP167 inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like), which we identified as novel MELK substrates and are important for stem-cell characteristics and invasiveness.?The compound suppressed mammosphere formation of breast cancer cells and exhibited significant tumor growth suppression in xenograft studies using breast, lung, prostate, and pancreas cancer cell lines in mice by both intravenous and oral administration.?This MELK inhibitor should be a promising compound possibly to suppress the growth of tumor-initiating cells and be applied for treatment of a wide range of human cancer. |
| Molecular Weight | 523.88 |
| Formula | C25H29Cl3N4O2 |
| Cas No. | 1431698-10-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 33 mg/mL (63 mM), Sonication is recommended. H2O: 7.14 mg/mL (13.63 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
Preview
Related Tags: buy OTSSP167 hydrochloride | purchase OTSSP167 hydrochloride | OTSSP167 hydrochloride cost | order OTSSP167 hydrochloride | OTSSP167 hydrochloride chemical structure | OTSSP167 hydrochloride in vitro | OTSSP167 hydrochloride formula | OTSSP167 hydrochloride molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.