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OTSSP167 hydrochloride

OTSSP167 hydrochloride
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Purity:99.97%
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OTSSP167 hydrochloride

Catalog No. T21559Cas No. 1431698-10-0
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
2 mg$48In Stock
5 mg$80In Stock
10 mg$122In Stock
25 mg$198In Stock
50 mg$372In Stock
100 mg$556In Stock
1 mL x 10 mM (in DMSO)$93In Stock
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Product Introduction

Bioactivity
Description
OTSSP167 hydrochloride is a highly potent inhibitor of MELK(IC50 : 0.41 nM).
Targets&IC50
MELK:0.41 nM (IC50)
In vitro
OTSSP167 is a highly potent MELK inhibitor with IC of 0.41 nM.?OTSSP167 inhibited the phosphorylation of PSMA1 (proteasome subunit alpha type 1) and DBNL (drebrin-like), which we identified as novel MELK substrates and are important for stem-cell characteristics and invasiveness.?The compound suppressed mammosphere formation of breast cancer cells and exhibited significant tumor growth suppression in xenograft studies using breast, lung, prostate, and pancreas cancer cell lines in mice by both intravenous and oral administration.?This MELK inhibitor should be a promising compound possibly to suppress the growth of tumor-initiating cells and be applied for treatment of a wide range of human cancer.
Chemical Properties
Molecular Weight523.88
FormulaC25H29Cl3N4O2
Cas No.1431698-10-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 33 mg/mL (63 mM), Sonication is recommended.
H2O: 7.14 mg/mL (13.63 mM), Sonication is recommended.
Solution Preparation Table
H2O/DMSO
1mg5mg10mg50mg
1 mM1.9088 mL9.5442 mL19.0883 mL95.4417 mL
5 mM0.3818 mL1.9088 mL3.8177 mL19.0883 mL
10 mM0.1909 mL0.9544 mL1.9088 mL9.5442 mL
DMSO
1mg5mg10mg50mg
20 mM0.0954 mL0.4772 mL0.9544 mL4.7721 mL
50 mM0.0382 mL0.1909 mL0.3818 mL1.9088 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

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