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PARP-1-IN-2
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.PARP-1-IN-2 induced apoptosis in A549 cells.
Catalog No. T62281Cas No. 684234-55-7
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Purity:98.82%
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PARP-1-IN-2
Catalog No. T62281Cas No. 684234-55-7
PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.PARP-1-IN-2 induced apoptosis in A549 cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $98 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $397 | In Stock | |
| 25 mg | $663 | In Stock | |
| 50 mg | $945 | In Stock | |
| 100 mg | $1,280 | In Stock | |
| 500 mg | $2,570 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $262 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | PARP-1-IN-2 is a potent PARP1 inhibitor that crosses the blood-brain barrier (IC50: 149 nM).PARP-1-IN-2 showed significant antiproliferative activity against the human lung adenocarcinoma epithelial cell line A549 in cellular assays.PARP-1-IN-2 induced apoptosis in A549 cells. |
| Targets&IC50 | PARP1:149 ± 11.0 nM |
| In vitro | PARP-1-IN-2 (compound 11g) (0-10 μM, 24-48 h) exhibits significant anti-proliferative activity against A549 cells without notable cytotoxicity on HFF cells.[1] PARP-1-IN-2 (0-10 μM, 24 h) reduces pro-caspase-3 and phosphorylated AKT expression, while increasing caspase-3, caspase-9 protein, and cleaved PARP-1 expression.[1] |
| Molecular Weight | 424.28 |
| Formula | C22H15Cl2N3O2 |
| Cas No. | 684234-55-7 |
Storage & Solubility Information
| Storage | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 9 mg/mL (21.21 mM), Sonication is recommended.  | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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