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PF-3882845
🥰Excellent
Catalog No. T16502Cas No. 1023650-66-9
Alias PF3882845
PF-3882845 is an orally available and selective salicorticoid receptor (MR) antagonist that binds to the progesterone receptor (PR) and can be used to study endocrine diseases and urogenital disorders.
PF-3882845
🥰Excellent
Catalog No. T16502Alias PF3882845Cas No. 1023650-66-9
PF-3882845 is an orally available and selective salicorticoid receptor (MR) antagonist that binds to the progesterone receptor (PR) and can be used to study endocrine diseases and urogenital disorders.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $85 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $293 | In Stock | |
| 25 mg | $497 | In Stock | |
| 50 mg | $831 | In Stock |
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | PF-3882845 is an orally available and selective salicorticoid receptor (MR) antagonist that binds to the progesterone receptor (PR) and can be used to study endocrine diseases and urogenital disorders. |
| Targets&IC50 | progesterone receptor:310 nM, mineralocorticoid receptor:2.7 nM |
| In vivo | In male Sprague-Dawley rats, PF-3882845 exhibited moderate bioavailability (F 86%) after oral administration (2 mg/kg). When administered intravenously (2 mg/kg), PF-3882845 exhibited a shorter terminal elimination half-life (T1/2 1.7 hours), which was associated with its higher plasma clearance (CL 9.8 mL/min/kg) and larger volume of distribution (Vdss 1.4 mL/kg). PF-3882845 has hypotensive, urinary albumin-reducing and renoprotective effects in Dahl SS rats. [1] |
| Alias | PF3882845 |
| Molecular Weight | 419.9 |
| Formula | C24H22ClN3O2 |
| Cas No. | 1023650-66-9 |
| Smiles | ClC=1C=C(N2[C@H]([C@@]3(C(=N2)C=4C(CC3)=CC(C(O)=O)=CC4)[H])C5CCCC5)C=CC1C#N |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (19.05 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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