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Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy. |
In vivo | PF-3882845 shows moderate oral bioavailability (F 86%) following oral administration (2 mg/kg) in male Sprague-Dawley rats. PF-3882845 displays terminal elimination half-lives (T1/2 1.7 h) due to high plasma clearance (CL 9.8 mL/min/kg) combined with large volumes of distribution (Vdss 1.4 mL/kg respectively) following intravenous administration (2 mg/kg) in male Sprague-Dawley rats. PF-3882845 decreases blood pressure, decreases urinary albumin, and protects kidney in Dahl SS rat [1]. |
Molecular Weight | 419.9 |
Formula | C24H22ClN3O2 |
Cas No. | 1023650-66-9 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
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