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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $34 | In Stock | |
5 mg | $80 | In Stock | |
10 mg | Inquiry | In Stock | |
50 mg | Inquiry | Backorder | |
1 mL x 10 mM (in DMSO) | $89 | In Stock |
Description | Raptinal activates caspase-3 directly and initiates intrinsic caspase-dependent apoptosis pathway in multiple cell lines. |
In vitro | In human gastric cancer cell lines AGS, MKN28, and MKN45, Raptinal(10 μM) induces the cleavage of pro-caspase-3 into the active form. Raptinal induces death against various cancer and non-cancerous cell lines (IC50 = 0.7-3.4 μM)[2]. |
In vivo | In B16-F10 and 4T1 models, intraperitoneal administration of Raptinal (20 mg/kg) exerts anticancer activity. In C57BL/6 mice, intravenous administration of Raptinal (37.5 mg/kg) shows the peak plasma concentration and elimination half-life of 54.40.9 μg/mL and 92.1 minutes, respectively[2]. |
Molecular Weight | 386.44 |
Formula | C28H18O2 |
Cas No. | 1176-09-6 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
Solubility Information | DMSO: 18.0 mg/mL (46.6 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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