Shopping Cart
- Remove All
- Your shopping cart is currently empty
Reldesemtiv (CK-2127107) is a selective fast skeletal muscle troponin activator with an EC50 of 3.4 μM, enhancing exercise performance in heart failure models.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 139 € | In Stock | |
5 mg | 305 € | In Stock | |
10 mg | 463 € | In Stock | |
25 mg | 747 € | In Stock | |
50 mg | 1.007 € | In Stock | |
1 mL x 10 mM (in DMSO) | 335 € | In Stock |
Description | Reldesemtiv (CK-2127107) is a selective fast skeletal muscle troponin activator with an EC50 of 3.4 μM, enhancing exercise performance in heart failure models. |
In vitro | Reldesemtiv selectively binds to the fast skeletal troponin complex and sensitizes to calcium [1]. |
In vivo | Reldesemtiv increases sarcomeric Ca2+ sensitivity in skinned LAD-HF skeletal fibers. In exercise-intolerant LAD-HF rats, Reldesemtiv (10 mg/kg; p.o.) obviously improves rotarod performance. Reldesemtiv (10 mg/kg; i.v.) enhances Ca2+ sensitivity in fast skeletal muscle fibers and increases muscle force in response to submaximal stimulation frequencies[1]. |
Alias | CK-2127107 |
Molecular Weight | 384.38 |
Formula | C19H18F2N6O |
Cas No. | 1345410-31-2 |
Smiles | NC(=O)c1ccn(c1)-c1cnc(NC[C@@]2(C[C@H](F)C2)c2ncccc2F)nc1 |
Relative Density. | 1.48 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 225 mg/mL (585.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.