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Reldesemtiv

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Catalog No. T16728Cas No. 1345410-31-2
Alias CK-2127107

Reldesemtiv (CK-2127107) is a selective fast skeletal muscle troponin activator with an EC50 of 3.4 μM, enhancing exercise performance in heart failure models.

Reldesemtiv

Reldesemtiv

🥰Excellent
Purity: 95.11%
Catalog No. T16728Alias CK-2127107Cas No. 1345410-31-2
Reldesemtiv (CK-2127107) is a selective fast skeletal muscle troponin activator with an EC50 of 3.4 μM, enhancing exercise performance in heart failure models.
Pack SizePriceAvailabilityQuantity
1 mg139 €In Stock
5 mg305 €In Stock
10 mg463 €In Stock
25 mg747 €In Stock
50 mg1.007 €In Stock
1 mL x 10 mM (in DMSO)335 €In Stock
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Purity:95.11%
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Product Introduction

Bioactivity
Description
Reldesemtiv (CK-2127107) is a selective fast skeletal muscle troponin activator with an EC50 of 3.4 μM, enhancing exercise performance in heart failure models.
In vitro
Reldesemtiv selectively binds to the fast skeletal troponin complex and sensitizes to calcium [1].
In vivo
Reldesemtiv increases sarcomeric Ca2+ sensitivity in skinned LAD-HF skeletal fibers. In exercise-intolerant LAD-HF rats, Reldesemtiv (10 mg/kg; p.o.) obviously improves rotarod performance. Reldesemtiv (10 mg/kg; i.v.) enhances Ca2+ sensitivity in fast skeletal muscle fibers and increases muscle force in response to submaximal stimulation frequencies[1].
AliasCK-2127107
Chemical Properties
Molecular Weight384.38
FormulaC19H18F2N6O
Cas No.1345410-31-2
SmilesNC(=O)c1ccn(c1)-c1cnc(NC[C@@]2(C[C@H](F)C2)c2ncccc2F)nc1
Relative Density.1.48 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 225 mg/mL (585.4 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6016 mL13.0080 mL26.0159 mL130.0796 mL
5 mM0.5203 mL2.6016 mL5.2032 mL26.0159 mL
10 mM0.2602 mL1.3008 mL2.6016 mL13.0080 mL
20 mM0.1301 mL0.6504 mL1.3008 mL6.5040 mL
50 mM0.0520 mL0.2602 mL0.5203 mL2.6016 mL
100 mM0.0260 mL0.1301 mL0.2602 mL1.3008 mL

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