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Reldesemtiv

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Purity:95.11%

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COA HPLC HNMR

Reldesemtiv

Catalog No. T16728Cas No. 1345410-31-2

Reldesemtiv (CK-2127107) is a selective activator of fast skeletal muscle troponin with an EC50 of 3.4 μM. Reldesemtiv increases exercise performance in the heart failure model.

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Pack Size	Price	Availability
1 mg	$187	In Stock
5 mg	$397	In Stock
10 mg	$589	In Stock
25 mg	$945	In Stock
50 mg	$1,280	In Stock
1 mL x 10 mM (in DMSO)	$437	In Stock

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Product Introduction

Bioactivity

Description	Reldesemtiv (CK-2127107) is a selective activator of fast skeletal muscle troponin with an EC50 of 3.4 μM. Reldesemtiv increases exercise performance in the heart failure model.
In vitro	Reldesemtiv selectively binds to the fast skeletal troponin complex and sensitizes to calcium [1].
In vivo	Reldesemtiv increases sarcomeric Ca2+ sensitivity in skinned LAD-HF skeletal fibers. In exercise-intolerant LAD-HF rats, Reldesemtiv (10 mg/kg; p.o.) obviously improves rotarod performance. Reldesemtiv (10 mg/kg; i.v.) enhances Ca2+ sensitivity in fast skeletal muscle fibers and increases muscle force in response to submaximal stimulation frequencies[1].
Alias	CK-2127107

Chemical Properties

Molecular Weight	384.38
Formula	C19H18F2N6O
Cas No.	1345410-31-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225 mg/mL (585.4 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6016 mL	13.0080 mL	26.0159 mL	130.0796 mL
5 mM	0.5203 mL	2.6016 mL	5.2032 mL	26.0159 mL
10 mM	0.2602 mL	1.3008 mL	2.6016 mL	13.0080 mL
20 mM	0.1301 mL	0.6504 mL	1.3008 mL	6.5040 mL
50 mM	0.0520 mL	0.2602 mL	0.5203 mL	2.6016 mL
100 mM	0.0260 mL	0.1301 mL	0.2602 mL	1.3008 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

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