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Resiniferatoxin
🥰Excellent
Catalog No. T34295Cas No. 57444-62-9
Alias RTX, [3H]resiniferatoxin
Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE.
Resiniferatoxin
🥰Excellent
Purity: 99.12%
Catalog No. T34295Alias RTX, [3H]resiniferatoxinCas No. 57444-62-9
Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $456 | In Stock |
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Purity:99.12%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Resiniferatoxin ((+)-Resiniferatoxin) is a highly potent synthetic TRPV1 agonist that inhibits the production of Th1 cytokines and has anti-inflammatory activity, reducing serum levels of IL-12, INF-γ, IL-1β, TNF-α, NO, and PGE. |
| In vitro | METHODS: RAW264.7 cells were treated with LPS (100 ng/ml) and IFN-γ (3 ng ml−1) and then treated with Resiniferatoxin ((+)-Resiniferatoxin) (0.01, 0.1, 1, 10.24 h). The culture medium was collected for NO determination, and the cell lysates were subjected to SDS-PAGE to measure and quantify iNOS or COX-2 immunoreactivity. RESULTS At a concentration of 10 μM, Resiniferatoxin ((+)-Resiniferatoxin) inhibited LPS-induced NO production by 67±10% and 52±6%, respectively, and failed to affect LPS-induced COX-2 and PGE2 responses. [3] |
| In vivo | METHODS: Resiniferatoxin ((+)-Resiniferatoxin) (2 μg/10 μl) was injected intrathecally into the T2/T3 space of mice. Cardiac sympathetic nerve activity (CSNA) and cardiac electrophysiology were assessed two weeks later. RESULTS Intrathecal injection of Resiniferatoxin ((+)-Resiniferatoxin) significantly and selectively eliminated the expression of dorsal horn afferent markers (TRPV1 and calcitonin gene-related peptide) and reduced overactive CSNA. Electrophysiological studies have shown that intrathecal administration of Resiniferatoxin ((+)-Resiniferatoxin) can significantly reverse the prolongation of action potential duration (APD) and APD alternating hormones and reduce the inducibility of ventricular arrhythmias. [4] |
| Alias | RTX, [3H]resiniferatoxin |
| Molecular Weight | 628.71 |
| Formula | C37H40O9 |
| Cas No. | 57444-62-9 |
| Smiles | C[C@H]1[C@]23[C@]([C@@]4([C@](C(C)=C)(C1)O[C@](CC5=CC=CC=C5)(O2)O4)[H])(C=C(COC(CC6=CC(OC)=C(O)C=C6)=O)C[C@@]7(O)[C@]3(C=C(C)C7=O)[H])[H] |
| Relative Density. | 1.35g/cm3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: soluble |
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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