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Reslizumab
🥰Excellent
Catalog No. T12706Cas No. 241473-69-8
Alias Sch55700, DCP-835, DCP835, CEP-38072, CEP38072
Reslizumab (Sch 55700) is a humanized immunoglobulin G (IgG)4 κ monoclonal antibody that binds to human interleukin 5, thereby decreasing eosinophil production and survival.Reslizumab improves lung function, induces a decrease in eosinophil production and maturation, and may be used in the study of asthma.
Reslizumab
🥰Excellent
Catalog No. T12706Alias Sch55700, DCP-835, DCP835, CEP-38072, CEP38072Cas No. 241473-69-8
Reslizumab (Sch 55700) is a humanized immunoglobulin G (IgG)4 κ monoclonal antibody that binds to human interleukin 5, thereby decreasing eosinophil production and survival.Reslizumab improves lung function, induces a decrease in eosinophil production and maturation, and may be used in the study of asthma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $662 | In Stock | |
| 5 mg | $1,770 | In Stock | |
| 10 mg | $2,380 | In Stock | |
| 25 mg | $3,530 | In Stock | |
| 50 mg | $4,780 | In Stock |
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Concentration:6.02 mg/mL
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Product Introduction
Bioactivity
Chemical Properties
| Description | Reslizumab (Sch 55700) is a humanized immunoglobulin G (IgG)4 κ monoclonal antibody that binds to human interleukin 5, thereby decreasing eosinophil production and survival.Reslizumab improves lung function, induces a decrease in eosinophil production and maturation, and may be used in the study of asthma. |
| Targets&IC50 | IL-5 (human):20 pM (Kd), IL-5 (human):109 pM (KD), Ba/F3 cells:0.5 nM |
| In vitro | Reslizumab binds with high affinity to human IL-5 in Biacore surface plasmon resonance, KD = 109 pM and in kinetic exclusion assays, KD = 4.3 pM. [1] Reslizumab displays high affinity binding to hIL-5 (Kd = 20 pmol/l), inhibits the binding of hIL-5 to Ba/F3 cells (IC50 = 0.5 nmol/l) and blocks IL-5 mediated proliferation of human erythroleukemic TF-1 cells. [2] |
| In vivo | Intraperitoneal or intramuscular injection of 0-10 mg/kg Reslizumab inhibited pulmonary eosinophilia in allergic mice in a dose-dependent manner. [2] Intravenous injection of 30 mg/kg Reslizumab inhibited allergic bronchoconstriction but not histamine-induced bronchoconstriction in allergic guinea pigs. Intravenous injection of 0.1-1 mg/kg Reslizumab blocked pulmonary eosinophilia and neutrophilia induced by tracheal injection of hIL-5 in guinea pigs. [2] Intravenous 0.3 mg/kg Reslizumab blocked antigen-challenge-induced pulmonary eosinophilia for up to 6 months in allergic rhesus monkeys. [2] |
| Alias | Sch55700, DCP-835, DCP835, CEP-38072, CEP38072 |
| Cas No. | 241473-69-8 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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