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Resorcinolnaphthalein

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Purity:99.25%

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COA LCMS HNMR

Resorcinolnaphthalein

Catalog No. T13865Cas No. 41307-63-5

Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).

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Pack Size	Price	Availability
10 mg	$39	In Stock
25 mg	$64	In Stock
1 mL x 10 mM (in DMSO)	$43	In Stock

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Product Introduction

Bioactivity

Description	Resorcinolnaphthalein is a specific enhancer of angiotensin-converting enzyme 2 (ACE2) (EC50 value of 19.5 μM).
In vitro	ACE2 activity in a dose-dependent manner enhanced by Resorcinolnaphthalein (100 μM) and XNT (EC50 values of 19.5 μM and 20.1 μM, respectively).ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology.
In vivo	resorcinolnaphthalein enhanced ACE2 activity in a dose-dependent manner. Acute in vivo administration of the xanthenone resulted in a dose-dependent transient and robust decrease in blood pressure (at 10 mg/kg, spontaneously hypertensive rats decreased 71+/-9 mm Hg and Wistar-Kyoto rats decreased 21+/-8 mm Hg; P<0.05). Chronic infusion of the xanthenone (120 microg/day) resulted in a modest decrease in the spontaneously hypertensive rat blood pressure (17 mm Hg; 2-way ANOVA; P<0.05), whereas it had no effect in Wistar-Kyoto rats. Strikingly, the decrease in blood pressure was also associated with improvements in cardiac function and reversal of myocardial, perivascular, and renal fibrosis in the spontaneously hypertensive rats[1].

Chemical Properties

Molecular Weight	382.36
Formula	C24H14O5
Cas No.	41307-63-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 120 mg/mL (313.84 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6153 mL	13.0767 mL	26.1534 mL	130.7668 mL
5 mM	0.5231 mL	2.6153 mL	5.2307 mL	26.1534 mL
10 mM	0.2615 mL	1.3077 mL	2.6153 mL	13.0767 mL
20 mM	0.1308 mL	0.6538 mL	1.3077 mL	6.5383 mL
50 mM	0.0523 mL	0.2615 mL	0.5231 mL	2.6153 mL
100 mM	0.0262 mL	0.1308 mL	0.2615 mL	1.3077 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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