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Risankizumab

🥰Excellent
Catalog No. T76778Cas No. 1612838-76-2
Alias SKYRIZI, Risankizumab rzaa, BI-655066, ABBV 066

Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. It inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM. Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.

Risankizumab

Risankizumab

🥰Excellent
Purity: 98.3% (SEC-HPLC)
Catalog No. T76778Alias SKYRIZI, Risankizumab rzaa, BI-655066, ABBV 066Cas No. 1612838-76-2
Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. It inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM. Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.
Pack SizePriceAvailabilityQuantity
1 mg230 €In Stock
5 mg753 €In Stock
10 mg1.168 €In Stock
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Concentration:3.93 mg/mL
Purity:98.3% (SEC-HPLC)
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Product Introduction

Bioactivity
Description
Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. It inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM. Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.
Targets&IC50
IL-17:17 pM (cynomolgus), IL-17:2 pM (human), IL-23:10pM (kd,cynomolgus), IL-23:10pM (kd,human)
In vitro
With Kds <10 pM, Risankizumab (BI 655066) exhibits high affinity for human and cynomolgus IL23[3]. Risankizumab (BI 655066) inhibits endogenous (THP-1 cell generated) human IL23-induced and recombinant cynomolgus IL23-induced IL17 production with IC50s of 2 pM and 17 pM, respectively[2].
In vivo
In mice, Risankizumab (BI 655066) inhibits IL23-induced ear swelling and cytokine production following a single intraperitoneal (i.p.) dosage of 1 mg/kg[2].
AliasSKYRIZI, Risankizumab rzaa, BI-655066, ABBV 066
Chemical Properties
Molecular Weight145.85 kDa
Cas No.1612838-76-2
Storage & Solubility Information
Storagestore at low temperature | store at -20°C | Shipping with blue ice.

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