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Risankizumab
Catalog No. T76778Cas No. 1612838-76-2
Alias SKYRIZI, Risankizumab rzaa, BI-655066, ABBV 066
Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. It inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM. Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.
Risankizumab
Catalog No. T76778Alias SKYRIZI, Risankizumab rzaa, BI-655066, ABBV 066Cas No. 1612838-76-2
Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. It inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM. Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $243 | In Stock | |
| 5 mg | $793 | In Stock | |
| 10 mg | $1,230 | In Stock |
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Concentration:3.93 mg/mL
Purity:98.3% (SEC-HPLC)
Contact us for more batch information
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Product Introduction
Bioactivity
Chemical Properties
| Description | Risankizumab (BI 655066) is a humanized IgG monoclonal antibody (Kd <10 pM) targeting the IL-23 p19 subunit. It inhibits IL-17 production induced by human IL-23 in mouse splenocytes with an IC50 value of 2 pM. Risankizumab is used for the prevention and treatment of immune and inflammatory disorders such as psoriasis vulgaris, psoriatic arthritis, generalized pustular psoriasis, and erythrodermic psoriasis. |
| Targets&IC50 | IL-17:17 pM (cynomolgus), IL-17:2 pM (human), IL-23:10pM (kd,human), IL-23:10pM (kd,cynomolgus) |
| In vitro | With Kds <10 pM, Risankizumab (BI 655066) exhibits high affinity for human and cynomolgus IL23[3]. Risankizumab (BI 655066) inhibits endogenous (THP-1 cell generated) human IL23-induced and recombinant cynomolgus IL23-induced IL17 production with IC50s of 2 pM and 17 pM, respectively[2]. |
| In vivo | In mice, Risankizumab (BI 655066) inhibits IL23-induced ear swelling and cytokine production following a single intraperitoneal (i.p.) dosage of 1 mg/kg[2]. |
| Alias | SKYRIZI, Risankizumab rzaa, BI-655066, ABBV 066 |
| Molecular Weight | 145.85 kDa |
| Cas No. | 1612838-76-2 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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