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RMC-0331

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Purity:99.81%

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COA HPLC HNMR

RMC-0331

Catalog No. T38170Cas No. 2488788-52-7

RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.

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Pack Size	Price	Availability
1 mg	$148	In Stock
2 mg	$222	In Stock
5 mg	$372	In Stock
10 mg	$663	In Stock
25 mg	$1,370	In Stock
50 mg	$2,120	In Stock
100 mg	$3,160	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock

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Product Introduction

Bioactivity

Description	RMC-0331 (RM-023) is an orally available and potent SOS1 inhibitor.RMC-0331 has potential anticancer activity, blocking RAS activation by disrupting RAS-SOS1 interactions.
In vitro	The IC50 of RMC-0331 is 71 nM, as determined by in vitro GDP/GTP exchange rate measurements[1].
In vivo	In the SHP2 mutation model, RMC-0331 exhibits single-agent anti-tumor activity when administered orally at doses ranging from 100 to 250 mg/kg once daily in immunocompetent mice[1].
Alias	RM-023

Chemical Properties

Molecular Weight	499.91
Formula	C22H25ClF3N5O3
Cas No.	2488788-52-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (200.04 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0004 mL	10.0018 mL	20.0036 mL	100.0180 mL
5 mM	0.4001 mL	2.0004 mL	4.0007 mL	20.0036 mL
10 mM	0.2000 mL	1.0002 mL	2.0004 mL	10.0018 mL
20 mM	0.1000 mL	0.5001 mL	1.0002 mL	5.0009 mL
50 mM	0.0400 mL	0.2000 mL	0.4001 mL	2.0004 mL
100 mM	0.0200 mL	0.1000 mL	0.2000 mL	1.0002 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc