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Ro 8-4304
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Catalog No. T8447Cas No. 195988-65-9
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
Ro 8-4304
😃Good
Catalog No. T8447Cas No. 195988-65-9
Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $681 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Ro 8-4304 Hydrochloride is an antagonist of NMDA receptor with IC50 of 0.4 μM |
| Targets&IC50 | NMDA:0.4 μM |
| In vitro | Ro 8-4304 is a voltage-independent, non-competitive antagonist of NMDA receptors in rat cultured cortical neurones and exhibits a state-dependent mode of action similar to that described for ifenprodil.?The apparent affinity of Ro 8-4304 for the NMDA receptor increased in an NMDA concentration-dependent manner so that Ro 8-4304 inhibited 10 and 100 microM NMDA responses with IC50s of 2.3 and 0.36 microM, respectively.?Currents elicited by 1 microM NMDA were slightly potentiated in the presence of 10 microM Ro 8-4304, and Ro 8-4304 binding slowed the rate of glutamate dissociation from NMDA receptors |
| Molecular Weight | 370.42 |
| Formula | C21H23FN2O3 |
| Cas No. | 195988-65-9 |
| Relative Density. | 1.250 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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