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Rocepafant
🥰Excellent
Catalog No. T28607Cas No. 132579-32-9
Alias LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730
Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.
Rocepafant
🥰Excellent
Purity: 99.38%
Catalog No. T28607Alias LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730Cas No. 132579-32-9
Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $76 | In Stock | |
| 5 mg | $177 | In Stock | |
| 10 mg | $260 | In Stock | |
| 25 mg | $506 | In Stock | |
| 50 mg | $690 | In Stock | |
| 100 mg | $982 | In Stock |
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Purity:99.38%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Rocepafant (LAU8080) is a platelet-activating factor (PAF) antagonist that attenuates hypoxic-ischemic brain damage in neonatal rats.Rocepafant inhibits tumor necrosis factor-Afa-mediated cytotoxicity in mouse L929 tumor cells. |
| Targets&IC50 | PAF receptor:0.74 nM |
| In vivo | Ten patients with active disease were treated for 4 weeks with a PAF receptor antagonist, Rocepafant, given orally (40 mg twice daily). The treatment period was followed by a 4-week follow-up period. Clinical indicators of disease activity significantly improved during the treatment period, with a progressive return to baseline values during the follow-up period. No significant change in laboratory variables was observed. The tolerance of the treatment was excellent, and no clinical or laboratory evidence of side effects was recorded. These results must be confirmed in a controlled study, but suggest an anti-inflammatory effect.[4] |
| Alias | LAU-8080, LAU8080, LAU 8080, BN-50730, BN50730, BN 50730 |
| Molecular Weight | 535.08 |
| Formula | C26H23ClN6OS2 |
| Cas No. | 132579-32-9 |
| Smiles | CC=1N2C3=C(C4=C(S3)CN(C(NC5=CC=C(OC)C=C5)=S)CC4)C(=NCC2=NN1)C6=C(Cl)C=CC=C6 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (102.79 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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