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RORγt inverse agonist 14
RORγt inverse agonist 14
RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, demonstrating anti-inflammatory activity. It is utilized in the research of rheumatoid arthritis and psoriasis [1].
Catalog No. T72252Cas No. 2672496-70-5
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RORγt inverse agonist 14
Catalog No. T72252Cas No. 2672496-70-5
RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, demonstrating anti-inflammatory activity. It is utilized in the research of rheumatoid arthritis and psoriasis [1].
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $1,770 | 8-10 weeks | |
| 50 mg | $3,580 | 8-10 weeks | |
| 100 mg | $4,900 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | RORγt inverse agonist 14 (8e) is a potent, selective, and orally active compound with an EC50 of 2.5 nM, demonstrating anti-inflammatory activity. It is utilized in the research of rheumatoid arthritis and psoriasis [1]. |
| In vivo | RORγt inverse agonist 14 (8e) exhibits a half-life (t 1/2) of 11 hours following intravenous (iv) injection at 1 mg/kg. When administered orally at 4 mg/kg in mice, the compound achieves a peak concentration (t max) in 2 hours, with an oral bioavailability (%F) of 101 [1]. Additionally, dosages ranging from 5 to 20 mg/kg effectively reduce arthritic scores, comparable to the murine analog of the commercially available TNF decoy receptor, etanercept [1]. |
| Molecular Weight | 678.61 |
| Formula | C26H26F8N2O6S2 |
| Cas No. | 2672496-70-5 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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