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S-methyl DM1
S-methyl DM1, a thiomethyl derivative of Maytansine, binds to tubulin (Kd of 0.93 μM) and inhibits microtubule polymerization.
Catalog No. T12805Cas No. 912569-84-7
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S-methyl DM1
Catalog No. T12805Cas No. 912569-84-7
S-methyl DM1, a thiomethyl derivative of Maytansine, binds to tubulin (Kd of 0.93 μM) and inhibits microtubule polymerization.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,670 | 6-8 weeks | |
| 50 mg | $2,180 | 6-8 weeks | |
| 100 mg | $2,800 | 6-8 weeks |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | S-methyl DM1, a thiomethyl derivative of Maytansine, binds to tubulin (Kd of 0.93 μM) and inhibits microtubule polymerization. |
| Targets&IC50 | Tubulin:(kd)0.93 μM |
| In vitro | S-methyl DM1, the primary cellular or liver metabolite of antibody-maytansinoid conjugates prepared with thiol-containing maytansinoids DM1[1], inhibits microtubule assembly at a half-maximal concentration of 4 μM. At 100 nM, S-methyl-DM1 (84%) suppresses dynamic instability more effectively than Maytansine (45%). Tritiated S-methyl-DM1 binds to 37 high-affinity sites per microtubule (Kd of 0.1 μM)[1]. Minimal inhibition occurs at 200 pM and is maximal at 3 nM. S-methyl DM1 (IC50 of 330 pM) is slightly more potent than Maytansine (IC50 of 710 pM)[2]. In MCF7 cells, S-methyl DM1 induces up to 80% accumulation of cells in G2/M compared to 30% in controls[2]. |
| Molecular Weight | 752.31 |
| Formula | C36H50ClN3O10S |
| Cas No. | 912569-84-7 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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