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sAJM589
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Catalog No. T16839Cas No. 2089-82-9
Alias Benzo[a]phenazin-5-ol, 5-Hydroxybenzo[a]phenazine
sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels. Myc is a multifunctional nuclear phosphoprotein that plays a key role in cell cycle progression, apoptosis, and cellular transformation. sAJM589 inhibits the cellular proliferation of a variety of Myc-dependent cancer cell lines and the adherent, non-dependent growth of Raji cells’ Growth.
sAJM589
😃Good
Catalog No. T16839Alias Benzo[a]phenazin-5-ol, 5-Hydroxybenzo[a]phenazineCas No. 2089-82-9
sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels. Myc is a multifunctional nuclear phosphoprotein that plays a key role in cell cycle progression, apoptosis, and cellular transformation. sAJM589 inhibits the cellular proliferation of a variety of Myc-dependent cancer cell lines and the adherent, non-dependent growth of Raji cells’ Growth.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $82 | 5 days | |
| 1 mL x 10 mM (in DMSO) | $112 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | sAJM589 is a Myc inhibitor that dose-dependently disrupts Myc-Max heterodimers, thereby decreasing Myc protein levels. Myc is a multifunctional nuclear phosphoprotein that plays a key role in cell cycle progression, apoptosis, and cellular transformation. sAJM589 inhibits the cellular proliferation of a variety of Myc-dependent cancer cell lines and the adherent, non-dependent growth of Raji cells’ Growth. |
| Targets&IC50 | MYC:1.8 μM |
| In vitro | sAJM589 potently disrupts the Myc-Max heterodimer to reduce Myc protein levels in a dose-dependent manner (IC50: 1.8 μM). sAJM589 inhibits cellular proliferation in diverse Myc-dependent cancer cell lines and anchorage-independent growth of Raji cells [1]. |
| Alias | Benzo[a]phenazin-5-ol, 5-Hydroxybenzo[a]phenazine |
| Molecular Weight | 246.26 |
| Formula | C16H10N2O |
| Cas No. | 2089-82-9 |
| Smiles | OC=1C=C2N=C3C=CC=CC3=NC2=C4C=CC=CC14 |
| Relative Density. | 1.393 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | DMSO: 4 mg/mL (16.24 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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