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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $112 | In Stock | |
5 mg | $352 | In Stock | |
10 mg | $493 | In Stock | |
25 mg | $768 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,390 | In Stock | |
500 mg | $2,790 | In Stock |
Description | Salicyl-AMS is an inhibitor of mycobacterium auxin biosynthesis that inhibits the growth of mycobacterium in the presence of iron deficiency in vitro. |
In vitro | Salicyl-AMS is a potent inhibitor of salicylate adenylation enzymes used in bacterial siderophore biosynthesis and a promising lead compound for the treatment of tuberculosis.[1] |
In vivo | The mycobactin biosynthesis inhibitor Salicyl-AMS adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. We conducted a single-dose pharmacokinetic study and a monotherapy study of Salicyl-AMS with mice. Intraperitoneal injection yielded much better pharmacokinetic parameter values than oral administration did. Monotherapy of Salicyl-AMS at 5.6 or 16.7 mg/kg significantly inhibited M. tuberculosis growth in the mouse lung.[2] |
Molecular Weight | 466.43 |
Formula | C17H18N6O8S |
Cas No. | 863238-55-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 81.5 mg/mL (174.6 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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