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Salicyl-AMS

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Catalog No. T17176Cas No. 863238-55-5

Salicyl-AMS is an inhibitor of mycobacterium auxin biosynthesis that inhibits the growth of mycobacterium in the presence of iron deficiency in vitro.

Salicyl-AMS

Salicyl-AMS

🥰Excellent
Purity: 99.92%
Catalog No. T17176Cas No. 863238-55-5
Salicyl-AMS is an inhibitor of mycobacterium auxin biosynthesis that inhibits the growth of mycobacterium in the presence of iron deficiency in vitro.
Pack SizePriceAvailabilityQuantity
1 mg$67In Stock
5 mg$211In Stock
10 mg$296In Stock
25 mg$461In Stock
50 mg$592In Stock
100 mg$833In Stock
200 mg$1,120In Stock
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Purity:99.92%
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Product Introduction

Bioactivity
Description
Salicyl-AMS is an inhibitor of mycobacterium auxin biosynthesis that inhibits the growth of mycobacterium in the presence of iron deficiency in vitro.
In vitro
Salicyl-AMS is a potent inhibitor of salicylate adenylation enzymes used in bacterial siderophore biosynthesis and a promising lead compound for the treatment of tuberculosis.[1]
In vivo
The mycobactin biosynthesis inhibitor Salicyl-AMS adenosine] inhibits M. tuberculosis growth in vitro under iron-limited conditions. We conducted a single-dose pharmacokinetic study and a monotherapy study of Salicyl-AMS with mice. Intraperitoneal injection yielded much better pharmacokinetic parameter values than oral administration did. Monotherapy of Salicyl-AMS at 5.6 or 16.7 mg/kg significantly inhibited M. tuberculosis growth in the mouse lung.[2]
Chemical Properties
Molecular Weight466.43
FormulaC17H18N6O8S
Cas No.863238-55-5
SmilesNc1ncnc2n(cnc12)[C@@H]1O[C@H](COS(=O)(=O)NC(=O)c2ccccc2O)[C@@H](O)[C@H]1O
Relative Density.1.93 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 81.5 mg/mL (174.6 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1439 mL10.7197 mL21.4394 mL107.1972 mL
5 mM0.4288 mL2.1439 mL4.2879 mL21.4394 mL
10 mM0.2144 mL1.0720 mL2.1439 mL10.7197 mL
20 mM0.1072 mL0.5360 mL1.0720 mL5.3599 mL
50 mM0.0429 mL0.2144 mL0.4288 mL2.1439 mL
100 mM0.0214 mL0.1072 mL0.2144 mL1.0720 mL

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