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Seco-DUBA
Catalog No. T38611Cas No. 1227961-59-2
Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).
Seco-DUBA
Catalog No. T38611Cas No. 1227961-59-2
Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,289 | 7-10 days | |
| 5 mg | $4,000 | 7-10 days | |
| 10 mg | Inquiry | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Seco-DUBA, a duocarmycin (DUBA) prodrug, possess two hydroxyl groups suitable for antibody coupling through a linker. This compound, serving as a precursor, enables the synthesis of antibody-drug conjugates (ADCs). |
| In vitro | Seco-DUBA demonstrates dose-dependent reduction in cell viability over 144 hours across concentrations ranging from 0.0001 pM to 0.01 nM in SK-BR-3 cells, proving to be as potent and efficacious as DUBA[1]. Additionally, it exhibits high sensitivity in reducing the viability of SK-BR-3 (IC 50 =0.09), SK-OV-3 (IC 50 =0.43), and SW620 (IC 50 =0.09) cells[1]. This is further corroborated by a Cell Cytotoxicity Assay conducted on the SK-BR-3 cell line within the specified concentration and incubation period, affirming the dose-dependent decrease in cell viability[1]. |
| In vivo | Seco-DUBA, at a dosage of 89 µg/kg administered intravenously, is likely transformed into DUBA almost instantaneously in Wistar rats, as indicated in pharmacokinetic analysis[1]. |
| Molecular Weight | 526.98 |
| Formula | C29H23ClN4O4 |
| Cas No. | 1227961-59-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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