Shopping Cart
- Remove All
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $269 | In Stock | |
5 mg | $666 | In Stock | |
10 mg | $948 | In Stock | |
25 mg | $1,420 | In Stock | |
50 mg | $1,890 | In Stock | |
100 mg | $2,570 | In Stock | |
1 mL x 10 mM (in DMSO) | $783 | In Stock |
Description | SETDB1-TTD-IN-1 is a potent, selective, and endogenous binder-competitive inhibitor of SETDB1-TTD with a Kd of 88 nM. |
Targets&IC50 | SETDB1-TTD:88 nM(Kd) |
In vitro | SETDB1-TTD-IN-1, at concentrations ranging from 2.5 to 40 μM, effectively stabilizes the SETDB1-TTD protein in a dose-dependent manner within HEK293T cells. Similarly, at these concentrations over a 24-hour period, it notably alters the expression of 72 genes in THP-1 cells, a human acute monocytic leukemia cell line. Additionally, SETDB1-TTD-IN-1 demonstrates binding affinity to 53BP1 and JMJD2A proteins, with dissociation constants (Kds) of 4.3 μM and 86 μM, respectively. However, it lacks activity against 14 out of 16 tested tudor domains, exhibiting Kds greater than 100 μM. |
Molecular Weight | 469.58 |
Formula | C28H31N5O2 |
Cas No. | 2755823-12-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 45 mg/mL (95.83 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.