keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 113.00 | |
5 mg | In stock | $ 288.00 | |
10 mg | In stock | $ 486.00 | |
25 mg | In stock | $ 778.00 | |
50 mg | In stock | $ 1,070.00 | |
100 mg | In stock | $ 1,430.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 259.00 |
Description | Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. |
In vitro | Sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells;?this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity.?The inhibitory mechanism of sphondin on IL-1beta-induced COX-2 expression may be, at least in part, through suppression of NF-kappaB activity. Sphondin may have the therapeutic potential as an anti-inflammatory drug on airway inflammation[1]. |
In vivo | Sphondin, showed anti-proliferative activity and caused G2/M arrest at concentrations of 0.05-15.0 Μm[2]. |
Source |
Molecular Weight | 216.19 |
Formula | C12H8O4 |
CAS No. | 483-66-9 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (138.77 mM)
You can also refer to dose conversion for different animals. More
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sphondin 483-66-9 GPCR/G Protein Immunology/Inflammation Neuroscience Prostaglandin Receptor COX airway anti-inflammatory epithelial Cyclooxygenase pulmonary inflammation inhibit PGE2 A549 Inhibitor COX-2 inhibitor