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sphondin

Catalog No. T5758   CAS 483-66-9

Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.

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sphondin Chemical Structure
sphondin, CAS 483-66-9
Pack Size Availability Price/USD Quantity
1 mg In stock $ 113.00
5 mg In stock $ 288.00
10 mg In stock $ 486.00
25 mg In stock $ 778.00
50 mg In stock $ 1,070.00
100 mg In stock $ 1,430.00
1 mL * 10 mM (in DMSO) In stock $ 259.00
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Purity: 99.71%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells.
In vitro Sphondin inhibits IL-1beta-induced PGE(2) release in A549 cells;?this inhibition is mediated by suppressing of COX-2 expression, rather than by inhibiting COX-2 enzyme activity.?The inhibitory mechanism of sphondin on IL-1beta-induced COX-2 expression may be, at least in part, through suppression of NF-kappaB activity. Sphondin may have the therapeutic potential as an anti-inflammatory drug on airway inflammation[1].
In vivo Sphondin, showed anti-proliferative activity and caused G2/M arrest at concentrations of 0.05-15.0 Μm[2].
Source
Molecular Weight 216.19
Formula C12H8O4
CAS No. 483-66-9

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (138.77 mM)

TargetMolReferences and Literature

1. Yang L L , Liang Y C , Chang C W , et al. Effects of sphondin, isolated from Heracleum laciniatum, on IL–1β-induced cyclooxygenase-2 expression in human pulmonary epithelial cells[J]. Life Sciences, 2002, 72(2):199-213. 2. Sumiyoshi M , Sakanaka M , Masahiko Taniguchi…. Anti-tumor effects of various furocoumarins isolated from the roots, seeds and fruits ofAngelicaandCnidiumspecies under ultraviolet A irradiation[J]. Journal of Natural Medicines, 2014, 68(1):83-94.

TargetMolCitations

1. Li S, Kelly C, Knob R, et al.Analysis of Coumarin-Based Phototoxins in Citrus-Derived Essential Oils Using Liquid Chromatography-Mass Spectrometry.Chromatographia.2023: 1-11.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Traditional Chinese Medicine Monomer Library GPCR Compound Library Natural Product Library for HTS HIF-1 Signaling Pathway Compound Library Nonsteroidal Anti-Inflammatory Compound Library Chinese Pharmacopoeia Natural Product Library Food as Medicine Compound Library Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library

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Keywords

sphondin 483-66-9 GPCR/G Protein Immunology/Inflammation Neuroscience Prostaglandin Receptor COX airway anti-inflammatory epithelial Cyclooxygenase pulmonary inflammation inhibit PGE2 A549 Inhibitor COX-2 inhibitor

 

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