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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T1532 | Pidotimod | Others , Antibacterial | |
Pidotimod is a synthetic dipeptide with immunomodulatory properties. | |||
T5036 | Cangrelor tetrasodium | GPR , P2Y Receptor | |
Cangrelor tetrasodium is a reversible and selective antagonist of platelet P2Y12, with prompt and potent antiplatelet effects. | |||
T9592 | OATD-01 | Others | |
OATD-01 is a highly active inhibitor of both Chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase). | |||
T12268 | NTP42 | Prostaglandin Receptor , PPAR | |
NTP42 is an antagonist of thromboxane A2 (TXA2) receptor(IC50 of 3.278 nM) | |||
T6792 | BQ-123 | BQ123 | Endothelin Receptor |
BQ-123 is a selective endothelin A receptor (ETA) antagonist with IC50 of 7.3 nM. Phase 2. | |||
T9699 | TAK-615 | LPA Receptor | |
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors. | |||
T9688 | CC-90001 | JNK | |
CC-90001 is an orally administered c-Jun N-terminal kinase (JNK) inhibitor with bias for JNK1 over JNK2. | |||
T6054 | GSK256066 | PDE | |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2. | |||
T11339 | Furegrelate sodium | U-63557A | PPAR |
Furegrelate sodium (U-63557A) is a selective thromboxane synthase inhibitor with oral activity. Furegrelate sodium(U-63557A) inhibits thromboxane A2 (TXA2) synthase in human platelet microsomes with an IC50 of 15 nM. | |||
T8313 | HCH6-1 | Others | |
HCH6-1 is a competitive Formyl peptide receptor 1 (FPR1) antagonist. | |||
T1841 | UNC0379 | Histone Methyltransferase | |
UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. | |||
T21712 | BAY 41-8543 | Others , Guanylate cyclase | |
BAY 41-8543 is a nitric oxide (NO)-independent stimulator of soluble guanylyl cyclase (sGC). | |||
T0120 | Voriconazole | UK-109496 | Antifection , Antifungal |
Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 CYP3A. | |||
T30258 | AZD-4818 | CCR1 antagonist | CCR |
AZD-4818 (CCR1 antagonist) is a chemokine CCR1 antagonist for the treatment of chronic obstructive pulmonary disease. | |||
T8900 | Seralutinib | GB002 | PDGFR |
Seralutinib (GB002) is an inhibitor of inhaled PDGFRα and PDGFRβ. It is used in the study for pulmonary arterial hypertension. | |||
T23322 | SB 452533 | TRP/TRPV Channel | |
SB 452533 is an antagonist of the vanilloid receptor 1(pKb: 7.8). | |||
T4503 | Talniflumate | Somalgen | Chloride channel , COX , N-Acetylglucosaminyltransferase , Anion Exchanger |
Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition o... | |||
T22358 | Etalocib | LY293111,VML295 | Apoptosis , Leukotriene Receptor , LTR |
Etalocib (LY293111) is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotriene B4 (LTB4) receptor or directly through 5'-l... | |||
T2561 | Macitentan | ACT-064992 | Apoptosis , Endothelin Receptor |
Macitentan (ACT-064992) is an endothelin receptor antagonist that is used in the therapy of pulmonary arterial hypertension (PAH). | |||
T4016 | BMS-986020 | AM152,BMS986020 | LPA Receptor , LPL Receptor |
BMS-986020 (AM152) is a selective antagonist of LPA1. | |||
T22245 | Arformoterol Tartrate | (R,R)-Formoterol tartrate | Adrenergic Receptor |
Arformoterol Tartrate ((R,R)-Formoterol tartrate) is the tartrate salt of arformoterol. Arformoterol is a long-acting beta-2 adrenergic agonist with bronchodilator activity[2]. | |||
T6445 | Cilomilast | SB-207499,Ariflo | PDE |
Cilomilast (SB-207499) is a potent PDE4 inhibitor with IC50 of about 110 nM, has anti-inflammatory activity and low central nervous system activity. Phase 3. | |||
T14782 | Brilaroxazine | RP5063 | Dopamine Receptor , 5-HT Receptor |
Brilaroxazine (RP5063) is a potent multimodal dopamine/5-HT modulator. Brilaroxazine is a partial agonist of dopamine D2, D3, and D4 receptors, 5-HT1A (Ki =1.5 nM) and 5-HT2A (Ki = 2.5 nM), and has antagonist activity 5-... | |||
T6547 | Ipratropium Bromide | Sch 1000,Itrop,Atrovent | AChR |
Ipratropium Bromide (Sch 1000) is a synthetic anticholinergic agent that is used as an inhalant for treatment of acute bronchospasm due to chronic bronchitis and emphysema. | |||
T0794 | Mepenzolate Bromide | Colibantil,Cantil,Cantilaque | AChR |
Mepenzolate Bromide (Colibantil) is a muscarinic antagonist used to treat gastrointestinal conditions. | |||
T0239 | Lonidamine | AF1890,DICA,Diclondazolic Acid | Apoptosis , Hexokinase , Mitochondrial Metabolism |
Lonidamine (Diclondazolic Acid) is an indazole carboxylic acid derivative, principally inhibiting aerobic glycolytic activity, by its effect on mitochondrially-bound hexokinase (HK). | |||
T26795 | PXS-4728A | BI-1467335,BI 1467335,BI1467335,BI-1467335 HCl | Monoamine Oxidase |
BI-1467335 HCl(BI 1467335) is a selective, orally active inhibitor of semicarbazide-sensitive amine oxidase (SSAO) that helps improve chronic obstructive pulmonary disease in mice[2]. | |||
T0098 | Ipratropium bromide monohydrate | Ipratropium bromide hydrate | AChR |
Ipratropium bromide monohydrate (Ipratropium bromide hydrate) is a muscarinic antagonist structurally related to ATROPINE but often considered safer and more effective for inhalation use. It is used for various bronchial... | |||
T21389 | Enprofylline | Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum | Others |
Enprofylline (Enprofilina), a bronchodilator, acts primarily as a competitive nonselective phosphodiesterase inhibitor. Enprofylline is used in asthma, chronic obstructive pulmonary disease, and in the management of sick... | |||
T8236 | RHC 80267 | U-57908 | Others , Phospholipase , COX , Acyltransferase , AChR |
RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets) | |||
T2663 | GTS-21 dihydrochloride | GTS 21 dihydrochloride,DMXB-A,DMBX-anabaseine | 5-HT Receptor , AChR |
GTS-21 dihydrochloride (DMBX-anabaseine) is a nAChRs agonist. nAChRs are neuron receptor proteins that activated by the binding of the neurotransmitter ACh. | |||
TP1016L | Aviptadil Acetate | Vasoactive Intestinal Peptide acetate salt | RAAS , SARS-CoV |
Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmona... | |||
T3034 | Eprazinone dihydrochloride | Resplen,Mucitux,Eftapan,NSC 317935,Eprazinone 2HCl | Others , Neurokinin receptor |
Eprazinone dihydrochloride (NSC 317935) is a mucolytic with antitussive and mucolytic effect. | |||
T1083L | Theophylline monohydrate | Quibron | HDAC , PDE , Adenosine Receptor |
Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a ... | |||
T9199 | GLPG2938 | 1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea | S1P Receptor , LPL Receptor |
GLPG2938 (1-(2-Ethoxy-6-(trifluoromethyl)pyridin-4-yl)-3-((5-methyl-6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)pyridazin-3-yl)methyl)urea) is a potent and selective antagonist of S1P2. | |||
T3148 | MK-571 sodium | L-660711 (sodium salt),L-660711 sodium salt,Verlukast sodium,L-660711,MK571,MK-571 sodium salt,Propanoic acid | Leukotriene Receptor , LTR |
MK-571 sodium (L-660711 sodium salt) is a selective, orally active antagonist of the CysLT1 receptor. MK-571 sodium is a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor used to demonstrate the role of Mrp2 in the ... | |||
T60388 | MIF098 | Others | |
MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be ... | |||
T3216 | Selexipag | NS-304,ACT-293987,Uptravi | Others , Prostaglandin Receptor |
Selexipag (ACT-293987)(NS-304) is prostacyclin receptor agonist that causes vasodilation in pulmonary vasculature and is used in the therapy of pulmonary arterial hypertension (PAH). | |||
T33386 | Milveterol HCl | Milveterol,GSK-159797,GSK 159797,GSK159797 | Adrenergic Receptor |
Milveterol HCl is a long-acting β(2) -adrenergic receptor agonist for the potential treatment of chronic obstructive pulmonary disease (COPD). | |||
T26760 | Bedoradrine sulfate | KUR1246,MN 221 sulfate,KUR1246 sulfate,MN221 sulfate,KUR 1246 sulfate,MN-221 sulfate,KUR 1246,KUR-1246 sulfate,MN-221,MN 221,MN221,KUR-1246 | Adrenergic Receptor |
Bedoradrine sulfate (MN-221 sulfate) is a super-selective beta2 agonist for the treatment of asthma exacerbations and chronic obstructive pulmonary disease. | |||
T72031 | BI 1015550 | PDE | |
BI 1015550 is an orally active inhibitor of PDE4B with an IC 50 value of 7.2 nM. BI 1015550 has good safety and potential applications in inflammation, allergic diseases, pulmonary fibrosis, and chronic obstructive pulmo... | |||
T4041 | Ziritaxestat | GLPG1690 | PDE |
Ziritaxestat (GLPG1690), an autotaxin inhibitor, currently being evaluated in an exploratory phase 2 study in idiopathic pulmonary fibrosis patients. | |||
T6147 | Nortadalafil | Demethyl Tadalafil | PDE |
Nortadalafil (Demethyl Tadalafil) is demethyl Tadalafil, which is a PDE5 inhibitor, treating erectile dysfunction (ED) ; and under the name Adcirca for the treatment of pulmonary arterial hypertensio. | |||
T12850 | Dilmapimod | SB-681323,GW 681323 | p38 MAPK , Autophagy |
Dilmapimod (SB-681323) is a potent inhibitor of p38 MAPK ,it potentially suppresses inflammation in chronic obstructive pulmonary disease. | |||
T9877 | Tiquizium | AChR | |
Tiquizium has effective Antimuscarinic effect, and causes significant bronchodilation in patients with chronic obstructive pulmonary disease. | |||
T60226 | CT52923 | PDGFR | |
CT52923 is a selective, orally active antagonist of platelet-derived growth factor receptor (PDGFR), functioning as an ATP-competitive inhibitor. It has versatile applications for researching an array of pathological dis... | |||
T6505 | Formoterol fumarate | Formoterol Hemifumarate,NSC 299587,Eformoterol Hemifumarate,CGP 25827A,Eformoterol,YM 08316 | Adrenergic Receptor |
Formoterol fumarate (Eformoterol Hemifumarate), an effective, specific and long-acting β2-adrenoceptor agonist, is utilized in the treatment of chronic obstructive pulmonary disease(COPD) and asthma. | |||
T15431 | Nemiralisib | GSK2269557 (free base),GSK2269557 | PI3K |
Nemiralisib(GSK-2269557 free base) is an orally available, potent and specific PI3Kδ inhibitor with a pKi of 9.9.Nemiralisib is used for the treatment of respiratory diseases including chronic obstructive pulmonary disea... | |||
T13106 | TD-5471 hydrochloride | Adrenergic Receptor | |
TD-5471 hydrochloride is a selective and potent long-acting human β2-adrenergic receptor agonist for the treatment of chronic obstructive pulmonary disease (COPD). | |||
T31207 | GSK233705 | Darotropium bromide,GSK 233705,GSK-233705B,GSK233705,GSK233705B,GSK-233705,GSK 233705B | AChR |
GSK233705 (Darotropium bromide) is a muscarinic receptor antagonist used in conjunction with the prevention and treatment of chronic obstructive pulmonary disease (COPD) and asthma in humans. |
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TN1355 | Acanthoside B | Immunology/Inflammation related | |
Acanthoside B is a lignan with anti-inflammatory and anti-amnesic effects. Acanthoside B can be used for studies about Alzheimer's disease and lung inflammation. | |||
T5758 | Sphondin | COX , Prostaglandin Receptor | |
Sphondin has anticonvulsant, anti-inflammatory, and anti-proliferative activities, it possessed an inhibitory effect on IL-1beta-induced increase in the level of COX-2 protein and PGE(2) release in A549 cells. | |||
T3409 | Plantamajoside | Y0160,C10485 | Others |
Plantamajoside (Y0160) has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity. | |||
T2223 | Kinetin | 6-Furfuryladenine,N6-Furfuryladenine | Others |
Kinetin (N6-Furfuryladenine), a type of cytokinin, has plant growth regulation effects. | |||
T1083 | Theophylline | Theo-24,1,3-Dimethylxanthine | Endogenous Metabolite , HDAC , PDE , Adenosine Receptor , Autophagy |
Theophylline (1,3-Dimethylxanthine) is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant activities. Theophylline inhibits the 3... | |||
T0518 | Methacycline hydrochloride | Rondomycin,Methacycline HCl | ribosome , Antibacterial , Antibiotic |
Methacycline hydrochloride (Rondomycin) is a broad-spectrum semisynthetic antibiotic related to TETRACYCLINE but excreted more slowly and maintaining effective blood levels for a more extended period. | |||
T3S0401 | Piceatannol 3'-O-glucoside | Piceatannol 3-glycoside,Quzhaqigan | Arginase , NO Synthase |
Piceatannol 3'-O-glucoside (Piceatannol 3-glycoside) increases pulmonary blood oxygen tension and decreases pulmonary interstitial edema, so it can protect lung injury. | |||
T1680 | Tolazoline hydrochloride | Imidaline hydrochloride,Imidaline (hydrochloride),Benzidazol hydrochloride,Tolazoline HCl,NSC35110 (hydrochloride) | Adrenergic Receptor |
Tolazoline hydrochloride (NSC35110 (hydrochloride)) is a non-selective competitive α-adrenergic receptor antagonist used in treatment of persistent pulmonary hypertension of the newborn. | |||
T2803 | Monocrotaline | Crotaline | TGF-beta/Smad |
Monocrotaline (Crotaline) is a pyrrolizidine alkaloid and a toxic plant constituent that poisons livestock and humans through the ingestion of contaminated grains and other foods. The alkaloid causes pulmonary artery hyp... | |||
T6S0105 | Peiminine | Zhebeinone,Fritillarine,Raddeanine,Verticinone | Others , Autophagy |
1. Peiminine (Raddeanine) is an effective inhibitor for lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury. | |||
T6S0119 | Dauricine | Apoptosis , Others , NF-κB | |
1. Dauricine has pulmonary toxicity, can produce pulmonary injury in CD-1 mice by the metabolism of Dauricine mediated by CYP3A. 2. Dauricinec can pass the blood-brain barrier, and that P-glycoprotein has an important ro... | |||
T3821 | Deapioplatycodin D | Deapi-platycodin D,DesapioplatycodinD | Others , HCV Protease |
Deapioplatycodin D and platycodin D can regulate the production and secretion of airway mucin and, at least in part, explains the traditional use of aqueous extract of APG as expectorants in diverse inflammatory pulmonar... | |||
T3S2007 | MRE-269 | MRE 269,ACT-333679,MRE269 | Prostaglandin Receptor |
MRE-269 (ACT-333679) is an orally available and long-acting prostacyclin receptor agonist prodrug. MRE-269(ACT-333679) is used for the treatment of pulmonary arterial hypertension. MRE-269(ACT-333679) is an active metabo... | |||
TN2089 | Platycodin D3 | HCV Protease , NF-κB | |
Platycodin D3 is a NF-κB inhibitor, it could as expectorants in diverse inflammatory pulmonary diseases, it can regulate the production and secretion of airway mucin; it can significantly enhance mitogen- and OVA-induced... | |||
T2S0690 | Ecliptasaponin A | Echinocystic acid-3-o-glucoside | Others |
1. Ecliptasaponin A (Echinocystic acid-3-o-glucoside) has protective effects against the pulmonary fibrosis induced by bleomycin via reducing the oxidative stress, lung tissue inflammation, and the subsequent epithelial-... | |||
T2946 | Tanshinone IIA sulfonate sodium | Tanshinone IIA sulfonate,Sodium Tanshinone IIA sulfonate,Tanshinone IIA sodium sulfonate,sodium | CaMK , P450 , Calcium Channel |
Tanshinone IIA sulfonate sodium (Tanshinone IIA sodium sulfonate) is a water-soluble derivative of tanshinone IIA extracted from Savia miltiorrhiza; a potent negative allosteric modulator of the human purinergic receptor... | |||
T4953 | Neotuberostemonine | NOS | |
Neotuberostemonine (NTS) is one of the main antitussive alkaloids in the root of Stemona tuberosa Lour, it has a significant protective effect on bleomycin (BLM)-induced pulmonary fibrosis through suppressing the recruit... | |||
T6S1049 | Wilforine | ATPase | |
Wilforine is a sesquiterpene pyridine alkaloid; important bioactive compound in T. wilfordii plants, and is effective in treating idiopathic pulmonary fibrosis. Wilforine has anti-inflammatory effect, which might be medi... | |||
TN1936 | Mogroside III-E | IL Receptor , TNF , TLR | |
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis... | |||
TN3469 | Aucuparin | 2,6-dimethoxy-4-phenylphenol | NADPH-oxidase |
Aucuparin (2,6-dimethoxy-4-phenylphenol) is a plant antibiotic with anti-inflammatory activity. Aucuparin inhibited pulmonary fibrosis in mouse models induced by bleomycin (BLM). ABTS and FRAP showed clear scavenging act... | |||
T4973 | Paraxanthine | 1,7-DIMETHYLXANTHINE | Endogenous Metabolite |
Paraxanthine (1,7-dimethylxanthine) is a metabolite of caffeine (sc-202514) which functions as an adenosine receptor ligand and a PARP-1 inhibitor in pulmonary epithelial cells. Studies suggest that Paraxanthine is struc... | |||
T3795 | Corilagin | Apoptosis , TLR , Reverse Transcriptase , Antibacterial , Autophagy | |
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the cytotoxicity of both cisplatin and doxorubicin on the Hep3B... | |||
T4S2063 | Tetrahydrocoptisine | STYLOPINE | ERK , p38 MAPK , NF-κB |
1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may invo... | |||
T40634 | Perilla ketone | ||
Perilla ketone is a naturally occurring xenobiotic compound that undergoes activation by pulmonary P450 cytochrome enzymes within the lung. This activation leads to the manifestation of severe pulmonary damage and the de... | |||
TN4654 | Niazirin | Others | |
The Moringa oleifera extract(including niaziridin and Niazirin) can successfully attenuate the development of pulmonary hypertension via direct vasodilatation and a potential increase in antioxidant activity. | |||
T20636 | Latrunculin B | LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644 | Antifungal |
Latrunculin B, an alkaloid from the Red Sea sponge, is an actin polymerization inhibitor with antifungal and antiprotozoal activity.Latrunculin B modulates the electrophysiological characteristics of the pulmonary veins ... | |||
TN1806 | Isotetrandrine | IL Receptor , NF-κB , MAPK | |
Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which m... |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00527 | SP-D Protein, Human, Recombinant (His) | Human | Human Cells |
Surfactant Pulmonary-Associated Protein D (SP-D) is a 43 kDa member of the collectin family of innate immune modulators. Its principal components consist of a collagen-like region and a C-terminal carbohydrate recognitio... | |||
TMPY-01059 | BMPR2 Protein, Human, Recombinant (His) | Human | HEK293 |
The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin... | |||
TMPY-00915 | Serpin A1 Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit... | |||
TMPY-01884 | MMP-8 Protein, Human, Recombinant | Human | HEK293 |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-02869 | MMP-12 Protein, Human, Recombinant (catalytic domain) | Human | E. coli |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-00566 | CCL18 Protein, Human, Recombinant (His) | Human | Yeast |
CCL18 is a chemotactic cytokine involved in the pathogenesis and progression of various disorders, including cancer. Proof showed high levels of CCL18 in the serum of epithelial ovarian carcinoma patients suggesting its... | |||
TMPY-02062 | SULT1A1 Protein, Human, Recombinant (His) | Human | E. coli |
Sulfate conjugation catalyzed by cytosolic sulfotransferase (SULT) enzymes. The SULTs are Phase II drug-metabolizing enzymes that catalyze the addition of a sulfuryl moiety to both endogenous compounds, including steroid... | |||
TMPY-01180 | CD86 Protein, Human, Recombinant (His) | Human | HEK293 |
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co... | |||
TMPY-00916 | Antithrombin III Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prog... | |||
TMPY-03802 | IL-17F Protein, Human, Recombinant (aa 31-163) | Human | E. coli |
Interleukin-17F (IL-17F) is a cytokine that shares sequence similarity with IL17. The most notable role of IL-17 is its involvement in inducing and mediating proinflammatory responses. IL-17 is commonly associated with a... | |||
TMPY-01442 | DMBT1 Protein, Human, Recombinant (His) | Human | HEK293 |
Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB d... | |||
TMPY-02751 | Cathepsin S Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS... | |||
TMPY-01475 | Jagged 1 Protein, Human, Recombinant (His) | Human | HEK293 |
Protein Jagged 1, also known as JAG1, JAGL1, and CD339, is a single-pass type I membrane protein that contains 1 DSL domain and 15 EGF-like domains. JAG1/Jagged 1 is widely expressed in adult and fetal tissues. The expre... | |||
TMPY-00735 | Cathepsin S Protein, Human, Recombinant (His) | Human | HEK293 |
Cathepsin S (CTSS), one of the lysosomal proteinases, has many important physiological functions in the nervous system, especially in process of extracellular matrix degradation and endocellular antigen presentation. CTS... | |||
TMPY-01919 | MMP-9 Protein, Mouse, Recombinant | Mouse | HEK293 |
Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen... | |||
TMPY-00888 | MMP-9 Protein, Human, Recombinant (His) | Human | HEK293 |
Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen... | |||
TMPY-01248 | MMP-9 Protein, Human, Recombinant | Human | HEK293 |
Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions, such as morphogen... | |||
TMPJ-01129 | SMAD1 Protein, Human, Recombinant (GST) | Human | E. coli |
SMAD Family Member 1 (SMAD1) is a member of the dwarfin/SMAD family. SMAD1 has the highest expression in the heart and skeletal muscle, containing one MAD homology 1 domain and one MAD homology 2 domain, As a transcripti... | |||
TMPY-00683 | BMPR2 Protein, Human, Recombinant (His & hFc) | Human | HEK293 |
The bone morphogenetic protein type II receptor (BMPR-II, or BMPR2), a receptor for the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) superfamily. Reduced expression or function of BMPR2 signalin... | |||
TMPY-06810 | SFTPB Protein, Human, Recombinant (His) | Human | CHO |
Pulmonary surfactant-associated protein B, also known as SFTPB and SP-B, contains one saposin A-type domain and three saposin B-type domains. SP-B is produced primarily by alveolar type II cells (AEC2) but also by noncil... | |||
TMPH-00975 | DDX1 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Ceruloplasmin is a blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the ... | |||
TMPJ-01146 | LGALSL Protein, Human, Recombinant (His) | Human | E. coli |
Galectin-Related Protein (LGALSL) is a 172 amino acid protein that contains one Galectin domain. LGALSL does not appear to bind carbohydrates or lactose as the critical residues required for binding are not conserved. LG... | |||
TMPK-00867 | EMAP-II/AIMP1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
The potent antiangiogenic and proinflammatory protein Endothelial Monocyte Activating Polypeptide II (EMAP II) has been described as a mediator of pulmonary vascular and alveolar formation and its expression is inversely... | |||
TMPH-03228 | Rabies virus (RABV) (strain SAD B19) Matrix Protein (His) | RABV | E. coli |
Cysteine protease that plays an important role in the inhibition of host innate immune response. Cleaves host elastins found in connective tissues, pulmonary surfactant protein A in the lungs, and the chemokine receptor ... | |||
TMPY-04321 | CHRNA5 Protein, Human, Recombinant (His) | Human | HEK293 |
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in ... | |||
TMPH-02846 | BICD2 Protein, Mouse, Recombinant (GST) | Mouse | E. coli |
Thrombin-like snake venom serine protease that clots fibrinogen (FGA) by releasing fibrinopeptide A. According to PubMed:8585090, only cleaves rabbit fibrinogen, whereas no specificity is described in PubMed:3910643 (tes... | |||
TMPH-03576 | Staphopain A Protein, S. aureus, Recombinant (His & Myc) | Staphylococcus aureus | E. coli |
Cysteine protease that plays an important role in the inhibition of host innate immune response. Cleaves host elastins found in connective tissues, pulmonary surfactant protein A in the lungs, and the chemokine receptor ... | |||
TMPY-00442 | Serpin A1 Protein, Rat, Recombinant (His) | Rat | HEK293 |
SerpinA1, also known as Alpha-1 antitrypsin (AAT), is a prototype member of the Serpin superfamily of the serine protease inhibitors. This serine protease inhibitor blocks the protease, neutrophil elastase. Alpha-1 antit... | |||
TMPJ-00361 | Endoglin Protein, Human, Recombinant (Trx & His) | Human | E. coli |
Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, a... | |||
TMPY-01481 | FLAP Protein, Human, Recombinant (His) | Human | Baculovirus-Insect Cells |
Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP), also known as FLAP, belongs to the MAPEG family. ALOX5AP/FLAP is an essential partner of 5-LO for this process. The FLAP (ALOX5AP) gene has been linked to risk fo... | |||
TMPJ-00505 | Serpin A1 Protein, Human, Recombinant (aa 25-418, His) | Human | Human Cells |
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent,... | |||
TMPJ-01104 | MPF Protein, Human, Recombinant (hFc) | Human | Human Cells |
Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Me... | |||
TMPJ-01105 | MPF Protein, Human, Recombinant (His) | Human | Human Cells |
Mesothelin is a cell surface glycoprotein whose expression is limited to mesothelial cells of the serosa (pleura, pericardium, and peritoneum) and epithelial cells of the trachea, tonsils, fallopian tube, and kidneys. Me... | |||
TMPH-01204 | DCAF4 Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Calcium-activated substrate recognition component of the SCF (SKP1-cullin-F-box protein) E3 ubiquitin-protein ligase complex, SCF(FBXL2), which mediates the ubiquitination and subsequent proteasomal degradation of target... | |||
TMPJ-00011 | CXCL2 Protein, Mouse, Recombinant | Mouse | E. coli |
C-X-C motif chemokine 2 (CXCL2,MIP-2) belongs to the intercrine alpha (chemokine CxC) family. It was originally identified as a heparin-binding protein secreted from a murine macrophage cell line in response to endotoxin... | |||
TMPU-00002 | SOS1-Cat Protein, Human, Recombinant (His) | Human | E. coli |
Defects in SOS1 are the cause of gingival fibromatosis 1 (GGF1) [MIM:135300]; also known as GINGF1. Gingival fibromatosis is a rare overgrowth condition. Defects in SOS1 are the cause of Noonan syndrome type 4 (NS4) [MIM... | |||
TMPH-02555 | C1QL1 Protein, Mouse, Recombinant (His) | Mouse | Yeast |
Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regul... | |||
TMPJ-00362 | MMP-2 Protein, Human, Recombinant (His) | Human | Human Cells |
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.It belongs to the matrix metalloproteinase (MMP) family. Matrix metallo... | |||
TMPY-00520 | MMP-8 Protein, Mouse, Recombinant (His) | Mouse | CHO |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-01844 | MMP-8 Protein, Mouse, Recombinant | Mouse | HEK293 |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-01377 | MMP-8 Protein, Human, Recombinant (His) | Human | HEK293 |
Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, ... | |||
TMPY-01303 | Serpin A3 Protein, Human, Recombinant (His) | Human | HEK293 |
SerpinA3, also known as Alpha 1-antichymotrypsin (AACT), is a plasma alpha globulin glycoprotein, and is a member of serpin superfamily of the serine protease inhibitors consisting of at least 35 members. SerpinA3 has be... | |||
TMPY-03571 | TROY Protein, Human, Recombinant (His) | Human | HEK293 |
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc... | |||
TMPY-03194 | TROY Protein, Human, Recombinant (hFc) | Human | HEK293 |
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc... | |||
TMPY-05386 | CD86 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 |
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co... | |||
TMPY-01650 | CD131 Protein, Human, Recombinant (His) | Human | HEK293 |
Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyt... | |||
TMPY-01206 | CD86 Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co... | |||
TMPY-02016 | CD86 Protein, Rat, Recombinant (His) | Rat | HEK293 |
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co... | |||
TMPY-03646 | CD86 Protein, Cynomolgus, Rhesus, Recombinant (His) | Cynomolgus,Rhesus | HEK293 |
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co... | |||
TMPY-05246 | CD86 Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
CD86, also known as B-lymphocyte activation antigen B7-2 (referred to as B70), is a member of the cell surface immunoglobulin superfamily. B7-2 exists predominantly as a monomer on cell surfaces and interacts with two co... | |||
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Cat No. | Product Name | ||
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L2200 | Tyrosine Kinase Inhibitor Library | 1033 compounds | |
A unique collection of 1033 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases; | |||
L8500 | HIF-1 Signaling Pathway Compound Library | 1352 compounds | |
A unique collection of 1352 HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies; |