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Oxitropium Bromide
Catalog No. T16417Cas No. 30286-75-0
Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.
Oxitropium Bromide
Catalog No. T16417Cas No. 30286-75-0
Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease.
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Product Introduction
Bioactivity
Chemical Properties
| Description | Oxitropium bromide is a mAChR antagonist. It is used as an anticholinergic bronchodilator drug for the treatment of asthma and chronic obstructive pulmonary disease. |
| In vitro | Incubation with Oxitropium bromide of the untreated diaphragm muscle and diaphragm muscle injected with endotoxin does not increase the force-frequency curves dose-dependently in vitro; but, it induces both types of muscle to be fatigue resistant. Oxitropium bromide is a muscarinic antagonist that blocks musucarinic acetylcholine receptors (mAChR) [1]. |
| In vivo | Oxitropium bromide effectively and durably counteracts the increase in resistance caused by acetylcholine (ACh), alongside inhibiting resistance spikes triggered by histamine, serotonin, leukotriene D4, or antigens. This compound, when inhaled, enhances force-frequency curves two hours post-administration and mitigates the reduction of these curves following endotoxin exposure in vivo. Furthermore, inhaling Oxitropium bromide at dosages of 1.5 μg or more significantly reduces the decline in mucus score due to intravenous histamine, albeit this effect is not observed with histamine inhalation [1][2][3]. |
| Molecular Weight | 412.32 |
| Formula | C19H26BrNO4 |
| Cas No. | 30286-75-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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