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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $84 | In Stock | |
2 mg | $123 | In Stock | |
5 mg | $198 | In Stock | |
10 mg | $328 | In Stock | |
25 mg | $579 | In Stock | |
50 mg | $928 | In Stock | |
100 mg | $1,260 | In Stock | |
500 mg | $2,530 | In Stock | |
1 mL x 10 mM (in DMSO) | $238 | In Stock |
Description | Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases. |
In vitro | Nebentan potassium also inhibited endothelin-1-induced vasoconstriction in isolated rat aorta with a pA(2) value of 7.6[1]. |
In vivo | In medullary rats, the DR(2) values of Nebentan potassium are 0.53 mg/kg and 0.77 mg/kg, respectively. When administered orally at 1 mg/kg, Nebentan potassium maintains its antagonistic effects in conscious rats for over 6.5 hours[1]. |
Alias | YM598 |
Molecular Weight | 529.61 |
Formula | C24H20KN5O5S |
Cas No. | 342005-82-7 |
Storage | keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (188.82 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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