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Nebentan potassium
🥰Excellent
Catalog No. T36008Cas No. 342005-82-7
Alias YM598
Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases.
Nebentan potassium
🥰Excellent
Purity: 98.92%
Catalog No. T36008Alias YM598Cas No. 342005-82-7
Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $84 | In Stock | |
| 2 mg | $123 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $328 | In Stock | |
| 25 mg | $579 | In Stock | |
| 50 mg | $928 | In Stock | |
| 100 mg | $1,260 | In Stock | |
| 500 mg | $2,530 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $238 | In Stock |
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Ambrisentan (BSF 208075) is an endothelin receptor antagonist used in the therapy of pulmonary arterial hypertension (PAH). Ambrisentan has been associated with a low rate of serum enzyme elevations during therapy but has yet to be implicated in cases of clinically apparent acute liver injury.
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Bosentan
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Bosentan (Benzenesulfonamide) is a sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.
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Purity:98.92%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Nebentan potassium (YM598) is an orally active and selective nonpeptide endothelin receptor (ETA receptor) antagonist.Nebentan potassium inhibits pulmonary arterial hypertension and may be useful in the study of neurologic and cardiovascular diseases. |
| Targets&IC50 | ETB:569 nM (Ki), ETA:0.679 nM (Ki) |
| In vitro | Nebentan potassium also inhibited endothelin-1-induced vasoconstriction in isolated rat aorta with a pA(2) value of 7.6[1]. |
| In vivo | In medullary rats, the DR(2) values of Nebentan potassium are 0.53 mg/kg and 0.77 mg/kg, respectively. When administered orally at 1 mg/kg, Nebentan potassium maintains its antagonistic effects in conscious rats for over 6.5 hours[1]. |
| Alias | YM598 |
| Molecular Weight | 529.61 |
| Formula | C24H20KN5O5S |
| Cas No. | 342005-82-7 |
| Smiles | O=S([N-]C1=NC(C2=NC=CC=N2)=NC(OC)=C1OC3=C(C=CC=C3)OC)(/C=C/C4=CC=CC=C4)=O.[K+] |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (188.82 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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