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BMS 182874
Catalog No. T26841Cas No. 153042-42-3
Alias BMS-182874, BMS182874
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.
BMS 182874
Catalog No. T26841Alias BMS-182874, BMS182874Cas No. 153042-42-3
BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $68 | In Stock | |
| 5 mg | $163 | In Stock | |
| 10 mg | $263 | In Stock | |
| 25 mg | $455 | In Stock | |
| 50 mg | $648 | In Stock | |
| 100 mg | $892 | In Stock | |
| 500 mg | $1,820 | In Stock |
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Purity:98.38%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BMS 182874 is an orally effective and highly selective endothelin receptor ETA antagonist with an IC50 value of 0.150 μM for ETA and a Ki value of 0.055 μM for ETA.BMS 182874 is able to reduce arterial pressure in a rat hypertension model induced by Deoxycorticosterone acetate. BMS 182874 was able to reduce Deoxycorticosterone-induced arterial pressure in a rat model of hypertension and can be used to study cardiovascular disease. |
| Targets&IC50 | ETA:0.150 μM, ETA:0.055 μM(Ki ) |
| In vitro | BMS-182874 (dimethyla minonalogue 11) is an effective functional antagonist of ETA-induced intracellular Ca2+ increase, with an IC50 value of 0.150 μM in vs-A10 cells. Ki value is 0.055 μM. The KB value in the rabbit carotid artery ring is 0.520 μM/[1] |
| In vivo | BMS 182874 (100 μM/kg; Single oral) administration causes a slow decrease of 25% in arterial blood pressure from the control level. After 12 and 24 hours of administration, arterial blood pressure remained 12% lower than the control level.[1] |
| Alias | BMS-182874, BMS182874 |
| Molecular Weight | 345.42 |
| Formula | C17H19N3O3S |
| Cas No. | 153042-42-3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (159.23 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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