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BMS 182874 hydrochloride

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BMS 182874 hydrochloride

Catalog No. T21790Cas No. 1215703-04-0

BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.

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Pack Size	Price	Availability
1 mg	$123	In Stock
5 mg	$252	In Stock
10 mg	$378	In Stock
25 mg	$635	In Stock
50 mg	$885	In Stock
100 mg	$1,230	In Stock
500 mg	$2,470	In Stock
1 mL x 10 mM (in DMSO)	$261	In Stock

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Product Introduction

Bioactivity

Description	BMS 182874 hydrochloride is a nonpeptide endothelin (El) receptor antagonist.
In vitro	BMS-l 82874 inhibited ET-l -stimulated inositol phosphate accumulation (KB 75 nM) and calcium mobilization (Ki = 140 nM) without suppressing the maximal responses in VSM-A10 cells. BMS-182874 competitively inhibited the binding of [125I]ET-1 to ETA receptors in rat vascular smooth muscle A10 (VSM-A10) cell membranes (Ki = 61 nM) and in CHO cells stably expressing the human ETA receptor (Ki = 48 nM), but was a weak inhibitor at ETB receptors (Ki > 50 μM) and non-ET receptors.
In vivo	BMS-182874 blunted the pressor response to exogenous ET-l when administered either orally (ED50 = 30 μmol/kg) or intravenously (ED50 = 24 μmol/kg) to conscious, normotensive rats.

Chemical Properties

Molecular Weight	381.88
Formula	C17H20ClN3O3S
Cas No.	1215703-04-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (130.93 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6186 mL	13.0931 mL	26.1862 mL	130.9312 mL
5 mM	0.5237 mL	2.6186 mL	5.2372 mL	26.1862 mL
10 mM	0.2619 mL	1.3093 mL	2.6186 mL	13.0931 mL
20 mM	0.1309 mL	0.6547 mL	1.3093 mL	6.5466 mL
50 mM	0.0524 mL	0.2619 mL	0.5237 mL	2.6186 mL
100 mM	0.0262 mL	0.1309 mL	0.2619 mL	1.3093 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

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